Fenobam | Enzo Life Sciences ALX-550-413-M025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Fenobam

catalog :

ALX-550-413-M025

quantity :

25 mg

citations: 4

Reference
Wallberg A, Nilsson K, Osterlund K, Peterson A, Elg S, Raboisson P, et al. Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues. Bioorg Med Chem Lett. 2006;16:1142-5 pubmed
Porter R, Jaeschke G, Spooren W, Ballard T, Büttelmann B, Kolczewski S, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005;315:711-21 pubmed
Wu W, McKown L, O Neill P. In vitro and in vivo metabolism of the antianxiolytic agent fenobam in the rat. J Pharm Sci. 1995;84:185-9 pubmed
Goldberg M, Salama A, Patel J, Malick J. Novel non-benzodiazepine anxiolytics. Neuropharmacology. 1983;22:1499-504 pubmed

product information

Product ID :

ALX-550-413

Catalog Number :

ALX-550-413-M025

Product Name :

Fenobam

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

16380255, 16040814, 7738798, 6142427

Product Description :

Potent and selective non-competitive mGluR5 antagonist that displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50=87nM). Acts at an allosteric modulatory site shared with MPEP (Prod. No. ALX-550-368) and binds mGluR5 with Kd values of 54nM and 31nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo.

Purity :

≥98% (1H-NMR)

Storage :

+4°C