JNJ 16259685 | Enzo Life Sciences ALX-550-412-M025 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

JNJ 16259685

catalog :

ALX-550-412-M025

quantity :

25 mg

citations: 6

Reference
Fukunaga I, Yeo C, Batchelor A. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol. 2007;151:870-6 pubmed
Knopfel T. Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype. Br J Pharmacol. 2007;151:723-4 pubmed
Steckler T, Oliveira A, Van Dyck C, Van Craenendonck H, Mateus A, Langlois X, et al. Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task. Behav Brain Res. 2005;164:52-60 pubmed
Steckler T, Lavreysen H, Oliveira A, Aerts N, Van Craenendonck H, Prickaerts J, et al. Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test. Psychopharmacology (Berl). 2005;179:198-206 pubmed
Mabire D, Coupa S, Adelinet C, Poncelet A, Simonnet Y, Venet M, et al. Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. J Med Chem. 2005;48:2134-53 pubmed
Lavreysen H, Wouters R, Bischoff F, Nóbrega Pereira S, Langlois X, Blokland S, et al. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004;47:961-72 pubmed

product information

Product ID :

ALX-550-412

Catalog Number :

ALX-550-412-M025

Product Name :

JNJ 16259685

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

17502847, 17502846, 16043241, 15821950, 15771457, 15555631

Product Description :

Sub-nanomolar potent, non-competitive mGlu1 antagonist (Ki=0.34nM). Inhibits glutamate-induced Ca2+ response at the human mGluR1 (IC50=0.55nM). Selective over mGluR5 (>400-fold). Displays no activity at mGluR2, mGluR3, mGluR4, mGluR6, AMPA or NMDA receptors (IC50>10µM). Centrally active following systemic administration.

Purity :

≥98% (TLC)

Storage :

+4°C