This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Tranilast
catalog :
ALX-550-409-M010
quantity :
10 mg
citations: 9
Reference
Petrilli J, Wadsworth S, Cooper K, Rodgers K, Siekierka J, diZerega G. Tranilast: a pharmaceutical candidate for reduction of adhesions using a novel approach. Semin Reprod Med. 2008;26:341-8 pubmed publisher
Platten M, Ho P, Youssef S, Fontoura P, Garren H, Hur E, et al. Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science. 2005;310:850-5 pubmed
Namazi M, Soma J. Tranilast: a novel weapon against insulin resistance. Med Hypotheses. 2005;64:1135-7 pubmed
Spiecker M, Lorenz I, Marx N, Darius H. Tranilast inhibits cytokine-induced nuclear factor kappaB activation in vascular endothelial cells. Mol Pharmacol. 2002;62:856-63 pubmed
Chikaraishi A, Hirahashi J, Takase O, Marumo T, Hishikawa K, Hayashi M, et al. Tranilast inhibits interleukin-1beta-induced monocyte chemoattractant protein-1 expression in rat mesangial cells. Eur J Pharmacol. 2001;427:151-8 pubmed
Takahashi A, Taniguchi T, Ishikawa Y, Yokoyama M. Tranilast inhibits vascular smooth muscle cell growth and intimal hyperplasia by induction of p21(waf1/cip1/sdi1) and p53. Circ Res. 1999;84:543-50 pubmed
Isaji M, Miyata H, Ajisawa Y, Takehana Y, Yoshimura N. Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br J Pharmacol. 1997;122:1061-6 pubmed
Yamada H, Tajima S, Nishikawa T, Murad S, Pinnell S. Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. J Biochem. 1994;116:892-7 pubmed
Suzawa H, Kikuchi S, Ichikawa K, Koda A. Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages. Jpn J Pharmacol. 1992;60:85-90 pubmed
product information
Product ID :
ALX-550-409
Catalog Number :
ALX-550-409-M010
Product Name :
Tranilast
Product Type :
Biochemical
Size :
10 mg
list of Pubmed id :
18756411, 16272121, 16272121, 15823702, 12237332, 11557268, 10082476, 9401770, 7533764, 1282575
Product Description :
Anti-inflammatory and anti-angiogenic agent. Inhibits VEGF-induced angiogenesis in vivo . Inhibits proliferation and tube formation of human endothelial cells in vitro. Also inhibits smooth muscle cell proliferation and prevents post-angiplasty retsenosis.Synthetic compound with structural similarity to the tryptophan (Trp) catabolites kynurenines. Tranilast ameliorates the disease severity in animal models of multiple sclerosis, in part, by inducing T cell tolerance. Trp degradation is an important mechanism in the maintenance of T cell tolerance in a variety of disease models and is mediated by the rate limiting enzyme indoleamine 2,3-dioxygenase (IDO).
ALTnames :
N-(3’,4’-Dimethoxycinnamoyl)anthranilic acid, 3,4-DAA
Purity :
≥95% (HPLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.