Cyclothiazide | Enzo Life Sciences ALX-550-338-M050 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Cyclothiazide

catalog :

ALX-550-338-M050

quantity :

50 mg

citations: 7

Reference
O Leary H, Bernard P, Castano A, Benke T. Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure. Neurobiol Dis. 2016;87:134-44 pubmed publisher
Cebers G, Liljequist S. Modulation of AMPA/kainate receptors by cyclothiazide increases cytoplasmic free Ca2+ and 45Ca2+ uptake in brain neurons. Eur J Pharmacol. 1995;290:105-15 pubmed
Nooney J, Feltz A. Inhibition by cyclothiazide of neuronal nicotinic responses in bovine chromaffin cells. Br J Pharmacol. 1995;114:648-55 pubmed
Wong L, Mayer M. Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors. Mol Pharmacol. 1993;44:504-10 pubmed
Trussell L, Zhang S, Raman I. Desensitization of AMPA receptors upon multiquantal neurotransmitter release. Neuron. 1993;10:1185-96 pubmed
Desai M, Burnett J, Ornstein P, Schoepp D. Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists. J Pharmacol Exp Ther. 1995;272:38-43 pubmed
Sharp R, May P, Mayne N, Snyder Y, Burnett J. Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes. Eur J Pharmacol. 1994;266:R1-2 pubmed

product information

Product ID :

ALX-550-338

Catalog Number :

ALX-550-338-M050

Product Name :

Cyclothiazide

Product Type :

Biochemical

Size :

50 mg

list of Pubmed id :

26706598, 8575524, 7735691, 7690448, 7686382, 7529311, 7511109

Product Description :

Potently inhibits the desensitization of AMPA receptors. Antihypertensive.

ALTnames :

3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-3,4-dihydro-3[2-norbornen-5-yl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Purity :

≥98% (HPLC (UV))

Storage :

+4°C