Diazoxide | Enzo Life Sciences ALX-550-260-G001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Diazoxide

catalog :

ALX-550-260-G001

quantity :

1 g

citations: 8

Reference
Sturgess N, Kozlowski R, Carrington C, Hales C, Ashford M. Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line. Br J Pharmacol. 1988;95:83-94 pubmed
Dunne M. Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells. FEBS Lett. 1989;250:262-6 pubmed
Quast U, Cook N. In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide. J Pharmacol Exp Ther. 1989;250:261-71 pubmed
Trube G, Rorsman P, Ohno Shosaku T. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch. 1986;407:493-9 pubmed
Dunne M, Yule D, Gallacher D, Petersen O. Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells. J Membr Biol. 1990;114:53-60 pubmed
Newgreen D, Bray K, McHarg A, Weston A, Duty S, Brown B, et al. The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim. Br J Pharmacol. 1990;100:605-13 pubmed
Dunne M. Block of ATP-regulated potassium channels by phentolamine and other alpha-adrenoceptor antagonists. Br J Pharmacol. 1991;103:1847-50 pubmed
Schwanstecher C, Dickel C, Ebers I, Lins S, Zünkler B, Panten U. Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells. Br J Pharmacol. 1992;107:87-94 pubmed

product information

Product ID :

ALX-550-260

Catalog Number :

ALX-550-260-G001

Product Name :

Diazoxide

Product Type :

Biochemical

Size :

1 g

list of Pubmed id :

3146398, 2666156, 2501478, 2431383, 2181144, 2167738, 1680516, 1422580

Product Description :

ATP-sensitive K+ channel activator. Effective concentrations in patch clamp experiments: 100-600µM. Blocks desensitization of AMPA receptors. Acts in pancreatic β-cells, where it is more potent than pinacidil (Prod. No. ALX-550-285). Antihypertensive and vasodilatory agent.

ALTnames :

7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Purity :

≥98% (HPLC)

Storage :

+4°C