This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
L-AP4
catalog :
ALX-550-026-M005
quantity :
5 mg
citations: 8
Reference
Schoepp D, Jane D, Monn J. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology. 1999;38:1431-76 pubmed
Nakajima Y, Iwakabe H, Akazawa C, Nawa H, Shigemoto R, Mizuno N, et al. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J Biol Chem. 1993;268:11868-73 pubmed
Evans R, Francis A, Jones A, Smith D, Watkins J. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982;75:65-75 pubmed
Koerner J, Cotman C. Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex. Brain Res. 1981;216:192-8 pubmed
Davies J, Watkins J. Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 1982;235:378-86 pubmed
Watkins J, Krogsgaard Larsen P, Honoré T. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharmacol Sci. 1990;11:25-33 pubmed
Thomsen C, Kristensen P, Mulvihill E, Haldeman B, Suzdak P. L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase. Eur J Pharmacol. 1992;227:361-2 pubmed
Trombley P, Westbrook G. L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor. J Neurosci. 1992;12:2043-50 pubmed
product information
Product ID :
ALX-550-026
Catalog Number :
ALX-550-026-M005
Product Name :
L-AP4
Product Type :
Biochemical
Size :
5 mg
list of Pubmed id :
10530808, 8389366, 7042024, 6266585, 6145492, 2155495, 1361913, 1318954
Product Description :
Selective agonist for group III mGluRs. NMDA agonist. Potent synaptic depressant.
ALTnames :
L(+)-2-Amino-4-phosphonobutanoic acid
Purity :
≥97% (HPLC)
Storage :
Ambient
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.