This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
protein
product name :
IL-35 (human):Fc (human), (recombinant)
catalog :
ALX-522-140-C010
quantity :
10 µg
citations: 5
Reference
Sha X, Meng S, Li X, Xi H, Maddaloni M, Pascual D, et al. Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway. J Biol Chem. 2015;290:19307-18 pubmed publisher
Filková M, Vernerová Z, Hulejová H, Prajzlerová K, Veigl D, Pavelka K, et al. Pro-inflammatory effects of interleukin-35 in rheumatoid arthritis. Cytokine. 2015;73:36-43 pubmed publisher
Chen Q, Swaminathan S, Yang D, Dai L, Sui H, Yang J, et al. Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway. PLoS ONE. 2013;8:e59194 pubmed publisher
Sharma R, Sung S, Ju C, Deshmukh U, Fu S, Ju S. Regulatory T-Cell (Treg) hybridoma as a novel tool to study Foxp3 regulation and Treg fate. J Autoimmun. 2011;37:113-21 pubmed publisher
Seyerl M, Kirchberger S, Majdic O, Seipelt J, Jindra C, Schrauf C, et al. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol. 2010;40:321-9 pubmed publisher
product information
Product ID :
ALX-522-140
Catalog Number :
ALX-522-140-C010
Product Name :
IL-35 (human):Fc (human), (recombinant)
Product Type :
Protein
Size :
10 µg
list of Pubmed id :
26085094, 25697137, 23527130, 21621978, 19950173
Background :
EBI3 (Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein; IL-27B; IL-27 subunit β) and IL-12A (IL-12 subunit p35; CLMF p35) form the heterodimeric cytokine IL-35 (interleukin-35) involved in T cell regulation. IL-35 is highly expressed in regulatory T cell (Treg) but not in effector or naive T cells. IL-35 is required for the suppressive function of T-reg in vitro and in vivo.
ALTnames :
Interleukin-35, EBI3:IL-12A, IL-27B:CLMF p35
Purity :
≥95% (SDS-PAGE)
Buffer :
Lyophilized. Contains PBS.
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.