CD137L (soluble) (human), (recombinant) | Enzo Life Sciences ALX-522-111-3010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

CD137L (soluble) (human), (recombinant)

catalog :

ALX-522-111-3010

quantity :

3 x 10 µg

citations: 1

Reference
Rabu C, Quéméner A, Jacques Y, Echasserieau K, Vusio P, Lang F. Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell co-stimulation activity. J Biol Chem. 2005;280:41472-81 pubmed

product information

Product ID :

ALX-522-111

Catalog Number :

ALX-522-111-3010

Product Name :

CD137L (soluble) (human), (recombinant)

Product Type :

Protein

Size :

3 x 10 µg

list of Pubmed id :

16204238

Product Description :

Biologically active CD137L (4-1BBL; TNFSF 9) comprising the whole extracellular tail domain (aa 49-93), which is important for the cross-linking of the protein that is essential for its biological activity.

Background :

The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.

ALTnames :

4-1BBL, TNFSF 9

Specificity :

Binds to human CD137 (4-1BB).

Purity :

≥95% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS and 5% trehalose.

Storage :

-20°C