This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
protein
product name :
Omentin 1 (human), (recombinant)
catalog :
ALX-522-108-C010
quantity :
10 µg
citations: 5
Reference
Rein Fischboeck L, Krautbauer S, Eisinger K, Pohl R, Meier E, Weiss T, et al. Hepatic scavenger receptor BI is associated with type 2 diabetes but unrelated to human and murine non-alcoholic fatty liver disease. Biochem Biophys Res Commun. 2015;467:377-82 pubmed publisher
Li D, Mei H, Pu J, Xiang X, Zhao X, Qu H, et al. Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2. Mol Cancer. 2015;14:47 pubmed publisher
Brunetti L, Leone S, Orlando G, Ferrante C, Recinella L, Chiavaroli A, et al. Hypotensive effects of omentin-1 related to increased adiponectin and decreased interleukin-6 in intra-thoracic pericardial adipose tissue. Pharmacol Rep. 2014;66:991-5 pubmed publisher
Brunetti L, Orlando G, Ferrante C, Recinella L, Leone S, Chiavaroli A, et al. Orexigenic effects of omentin-1 related to decreased CART and CRH gene expression and increased norepinephrine synthesis and release in the hypothalamus. Peptides. 2013;44:66-74 pubmed publisher
Tan B, Adya R, Farhatullah S, Lewandowski K, O Hare P, Lehnert H, et al. Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose. Diabetes. 2008;57:801-8 pubmed publisher
product information
Product ID :
ALX-522-108
Catalog Number :
ALX-522-108-C010
Product Name :
Omentin 1 (human), (recombinant)
Product Type :
Protein
Size :
10 µg
list of Pubmed id :
26431876, 25889839, 25443726, 23538212, 18174521
Product Description :
Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.
Background :
Omentin 1 (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been identified as a visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin.
ALTnames :
Intelectin-1, Endothelial lectin HL-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin
Purity :
≥95% (SDS-PAGE)
Buffer :
Lyophilized. Contains PBS.
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.