Netrin-1 (human), (recombinant) | Enzo Life Sciences ALX-522-100-2010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

Netrin-1 (human), (recombinant)

catalog :

ALX-522-100-2010

quantity :

2 x 10 µg

citations: 6

Reference
Tu T, Zhang C, Yan H, Luo Y, Kong R, Wen P, et al. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Res. 2015;25:275-87 pubmed publisher
SchÃ¤ker K, Bartsch S, Patry C, Stoll S, Hillebrands J, Wieland T, et al. The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development. J Biol Chem. 2015;290:6408-18 pubmed publisher
Delloye Bourgeois C, Fitamant J, Paradisi A, Cappellen D, Douc Rasy S, Raquin M, et al. Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med. 2009;206:833-47 pubmed publisher
Delloye Bourgeois C, Brambilla E, Coissieux M, Guenebeaud C, Pedeux R, Firlej V, et al. Interference with netrin-1 and tumor cell death in non-small cell lung cancer. J Natl Cancer Inst. 2009;101:237-47 pubmed publisher
Lourenço F, Galvan V, Fombonne J, Corset V, Llambi F, Muller U, et al. Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. Cell Death Differ. 2009;16:655-63 pubmed publisher
Fitamant J, Guenebeaud C, Coissieux M, Guix C, Treilleux I, Scoazec J, et al. Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci U S A. 2008;105:4850-5 pubmed publisher

product information

Product ID :

ALX-522-100

Catalog Number :

ALX-522-100-2010

Product Name :

Netrin-1 (human), (recombinant)

Product Type :

Protein

Size :

2 x 10 µg

list of Pubmed id :

25656845, 25586182, 19349462, 19211441, 19148186, 18353983

SPECIES REACTIVITY :

Human, Mouse, Rat

Background :

The Netrins (whose name means “one who guides” in Sanskrit) are a family of laminin-related secreted protein. In mice, human and rat, netrin-1, netrin-3/NTL2, Netrin-4 and G-Netrins have been cloned. Netrin-1 is predominantly expressed by floor plate cells as commissural axons extend toward the ventral midline. Netrin-1 induces axonal outgrowth, axon orientation and neuronal migration in neuronal development. It is chemoattractive for some neurons and chemorepellent for others. To carry its functions, netrin-1 interacts with specific receptors: DCC/Neogenin and UNC-5. These receptors belong to the family of “dependence receptors” that induce apoptosis in the absence of their respective ligand, and promote survival when bound to their ligand. The Netrin-1 mediated survival signal inhibits p53-induced apoptosis. Netrin-1 is also expressed in organs such as pancreas, lung, bowel, bone and mammary gland. In these tissues, netrin-1 has different roles such as invasion of epithelial cells, leukocytes migration, cell adhesion or angiogenesis. Netrin-1, as a survival factor, also contributes to the control of tumorigenesis. Historical results have shown that netrin-1 induces axon outgrowth and inhibits DCC- and UNC5H2-mediated apoptosis in HEK 293 cells.

Specificity :

Tests positive for binding to human Unc5b by ELISA. Previous lots produced from the same cell line bind to human, mouse and rat receptors UNC5H and DCC.

Purity :

≥90% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS.

Uses :

ELISA: binds to UNC5B at 15-1000 ng/ml.

Application Summary :

ELISA

Storage :

-20°C