TL1A (soluble) (human), (recombinant) | Enzo Life Sciences ALX-522-084-C010 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

TL1A (soluble) (human), (recombinant)

catalog :

ALX-522-084-C010

quantity :

10 µg

product information

Product ID :

ALX-522-084

Catalog Number :

ALX-522-084-C010

Product Name :

TL1A (soluble) (human), (recombinant)

Product Type :

Protein

Size :

10 µg

Background :

TL1A (TNFSF15), a ligand belonging to the tumor necrosis factor (TNF) family, is expressed predominantly by endothelial cells and monocytes. TL1a is upregulated by the proinflammatory cytokines TNF and IL-1 and also by immune complexes (IC). TL1 functions in T cell costimulation and Th1 polarization. On activated T cells, TL1A functions specifically via its surface-bound receptor DR3, (a member of the death-domain containing TNF receptor family) to promote cell survival and secretion of proinflammatory cytokines (1). The secreted decoy receptor 3 (DcR3), a soluble protein of the tumor necrosis factor receptor (TNFR) superfamily blocks the action of TL1A. TL1A can be released to circulate as a homotrimeric soluble form. Activation of DR3 by TL1A induced the formation of a signaling complex containing TRADD, TRAF2, and RIP and activated the NF-κB and the ERK, JNK, and p38 mitogen-activated protein kinase pathways. The TL1A/DR3 pathway plays an important role in Th1-mediated intestinal diseases, such as Crohn’s disease.

ALTnames :

TNFSF 15, VEGI

Specificity :

Binds human DR3 and DcR3.

Purity :

≥85% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS.

Uses :

Flow Cytometry: use together with Enhancer for Ligands (Prod. No. ALX-804-034) to detect human DR3 and DcR3.

Application Summary :

ELISA, FC

Storage :

-20°C