LAG-3 (human):Fc (human), (recombinant) | Enzo Life Sciences ALX-522-078-C050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

LAG-3 (human):Fc (human), (recombinant)

catalog :

ALX-522-078-C050

quantity :

50 µg

citations: 7

Reference
Juno J, Stalker A, Waruk J, Oyugi J, Kimani M, Plummer F, et al. Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment. Retrovirology. 2015;12:17 pubmed publisher
Brignone C, Grygar C, Marcu M, Schakel K, Triebel F. A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells. J Immunol. 2007;179:4202-11 pubmed
Triebel F, Hacene K, Pichon M. A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors. Cancer Lett. 2006;235:147-53 pubmed
Buisson S, Triebel F. LAG-3 (CD223) reduces macrophage and dendritic cell differentiation from monocyte precursors. Immunology. 2005;114:369-74 pubmed
Andreae S, Piras F, Burdin N, Triebel F. Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223). J Immunol. 2002;168:3874-80 pubmed
Huard B, Prigent P, Pages F, Bruniquel D, Triebel F. T cell major histocompatibility complex class II molecules down-regulate CD4+ T cell clone responses following LAG-3 binding. Eur J Immunol. 1996;26:1180-6 pubmed
Huard B, Prigent P, Tournier M, Bruniquel D, Triebel F. CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins. Eur J Immunol. 1995;25:2718-21 pubmed

product information

Product ID :

ALX-522-078

Catalog Number :

ALX-522-078-C050

Product Name :

LAG-3 (human):Fc (human), (recombinant)

Product Type :

Protein

Size :

50 µg

list of Pubmed id :

25810006, 17785860, 15946792, 15720438, 11937541, 8647185, 7589152

Background :

The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses.

ALTnames :

Lymphocyte activation gene-3, FDC protein, CD223

Specificity :

Binds to human, mouse and monkey MHC class II.

Purity :

≥99% (SDS-PAGE)

Buffer :

Liquid. In PBS.

Uses :

Flow Cytometry: Detection of MHC class II molecules in combination with fluorescently labelled Ab to IgG1.

Application Summary :

ELISA, FC

Storage :

-20°C