CD40 (human):COMP (human), (recombinant) | Enzo Life Sciences ALX-522-064-C010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

CD40 (human):COMP (human), (recombinant)

catalog :

ALX-522-064-C010

quantity :

10 µg

citations: 1

Reference
Holler N, Kataoka T, Bodmer J, Romero P, Romero J, Deperthes D, et al. Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors. J Immunol Methods. 2000;237:159-73 pubmed

product information

Product ID :

ALX-522-064

Catalog Number :

ALX-522-064-C010

Product Name :

CD40 (human):COMP (human), (recombinant)

Product Type :

Protein

Size :

10 µg

list of Pubmed id :

10725460

Background :

COMP (Cartilage Oligomeric Matrix Protein) also designated thrombospondin 5 (TSP 5) is an oligomeric protein synthesized by chondrocytes in all type of cartilage. It belongs to the thrombospondin family of extracellular proteins. It is a pentameric molecule forming a structure similar to a bouquet of flowers. It may have storage and delivery function for hydrophobic cell-signalling molecules such as vitamin D. COMP is a calcium-binding protein composed of 5 identical disulfide-linked subunits of 755 amino acids each with a high percentage of acidic residues (30%). The molecular weight of the homopentamer is 524 kDa, as determined by sedimentation equilibrium ultracentrifugation. Each subunit is composed of an N-terminal coiled-coil domain (unique to COMP), four epidermal growth factor (EGF)-type repeats, followed by eight calmodulin-like repeats and a globular C-terminal domain. The C-terminal domain binds to collagens I, II and IX. Chimeras composed of proteins fused to the pentamerization domain of COMP (aa 32-75) show an increased avidity compared to the protein alone. Historical results have shown that COMP is a potent blocker of mouse CD40L-dependent B cell proliferation without the requirement of any crosslinking reagent (enhancer).

ALTnames :

TNFRSF 5

Specificity :

Binds human CD40L (CD154).

Purity :

≥90% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS.

Storage :

-20°C