LTβR (human):Fc (human), (recombinant) | Enzo Life Sciences ALX-522-041-C050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

LTβR (human):Fc (human), (recombinant)

catalog :

ALX-522-041-C050

quantity :

50 µg

citations: 3

Reference
Bossen C, Ingold K, Tardivel A, Bodmer J, Gaide O, Hertig S, et al. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem. 2006;281:13964-71 pubmed
Silva Santos B, Pennington D, Hayday A. Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors. Science. 2005;307:925-8 pubmed
Rooney I, Butrovich K, Glass A, Borboroglu S, Benedict C, Whitbeck J, et al. The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J Biol Chem. 2000;275:14307-15 pubmed

product information

Product ID :

ALX-522-041

Catalog Number :

ALX-522-041-C050

Product Name :

LTβR (human):Fc (human), (recombinant)

Product Type :

Protein

Size :

50 µg

list of Pubmed id :

16547002, 15591166, 10799510

SPECIES REACTIVITY :

Human, Mouse

Background :

LTβR is a 75kDa type I transmembrane protein belonging to the TNF receptor family. It is 414 aa long and contains 4 cysteine-rich repeats in its extracellular domain. It is expressed on monocytes, fibroblasts, stromal and muscle cells. It is known to activate nuclear factor NF-κB, to interact with NIK and to induce cell death via TNF receptor-associated factor 3 (TRAF3). LTβR has two known ligands: LIGHT and LTα1β2. It has been shown to be involved in splenic architecture development, lymph node genesis and affinity maturation, as well as in the development of diabetes and colitis. It has been implicated in the induction of HIV replication and impairs prion replication in mice lacking follicular dendritic cells. Historical data has shown that LTβR inhibits human LIGHT- and LTα1β2-mediated effects, such as cytotoxic effects, on HT29 target cells.

ALTnames :

TNFRSF 3, Tumor necrosis factor receptor 2-related protein

Specificity :

Binds human and mouse LIGHT and LTα1β2.

Buffer :

Lyophilized. Contains PBS.

Uses :

ELISA: binds to LIGHT at 20-500 ng/ml. Detection of human membrane-bound LIGHT in combination with PAb to human IgG1.

Application Summary :

ELISA

Storage :

-20°C