TACI (human):Fc (human), (recombinant) | Enzo Life Sciences ALX-522-033-C050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

TACI (human):Fc (human), (recombinant)

catalog :

ALX-522-033-C050

quantity :

50 µg

citations: 6

Reference
Mongini P, Inman J, Han H, Fattah R, Abramson S, Attur M. APRIL and BAFF promote increased viability of replicating human B2 cells via mechanism involving cyclooxygenase 2. J Immunol. 2006;176:6736-51 pubmed
Bonci D, Hahne M, Felli N, Peschle C, De Maria R. Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis. Blood. 2004;104:3169-72 pubmed
He B, Chadburn A, Jou E, Schattner E, Knowles D, Cerutti A. Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL. J Immunol. 2004;172:3268-79 pubmed
Huard B, Arlettaz L, Ambrose C, Kindler V, Mauri D, Roosnek E, et al. BAFF production by antigen-presenting cells provides T cell co-stimulation. Int Immunol. 2004;16:467-75 pubmed
Schneider P, Takatsuka H, Wilson A, Mackay F, Tardivel A, Lens S, et al. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J Exp Med. 2001;194:1691-7 pubmed
Huard B, Schneider P, Mauri D, Tschopp J, French L. T cell costimulation by the TNF ligand BAFF. J Immunol. 2001;167:6225-31 pubmed

product information

Product ID :

ALX-522-033

Catalog Number :

ALX-522-033-C050

Product Name :

TACI (human):Fc (human), (recombinant)

Product Type :

Protein

Size :

50 µg

list of Pubmed id :

16709833, 15105291, 14978135, 14978020, 11733583, 11714784

SPECIES REACTIVITY :

Human, Mouse

Background :

TACI (transmembrane activator and CAML-interactor) is a 40kDa protein which belongs to the tumor necrosis factor (TNF) receptor family. TACI specifically binds to BAFF and APRIL, two members of the TNF family. Activation of TACI induces recruitment of TNF-R-associated factors (TRAF)-2, -5 and -6 leading to the activation of NFκB, NF-AT and AP1. APRIL and BAFF induce proliferation and IgM secretion. BAFF is involved in the onset of Systemic Lupus Erythematosus (SLE) in mice. Historical data has shown that TACI blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF-mediated B cell activation.

ALTnames :

TNFRSF 13B, Transmembrane activator and CAML interactor, CD267

Specificity :

Binds human and mouse (weak) BAFF and APRIL.

Purity :

≥95% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS.

Storage :

-20°C