CD134 (human):Fc (human), (recombinant) | Enzo Life Sciences ALX-522-022-C050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

CD134 (human):Fc (human), (recombinant)

catalog :

ALX-522-022-C050

quantity :

50 µg

citations: 1

Reference
Biagi E, Dotti G, Yvon E, Lee E, Pule M, Vigouroux S, et al. Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes. Blood. 2005;105:2436-42 pubmed

product information

Product ID :

ALX-522-022

Catalog Number :

ALX-522-022-C050

Product Name :

CD134 (human):Fc (human), (recombinant)

Product Type :

Protein

Size :

50 µg

list of Pubmed id :

15536147

SPECIES REACTIVITY :

Human, Mouse

Background :

The CD134 receptor (OX40) is a member of the tumor necrosis factor receptor (TNF-R) family. CD134 is a type I transmembrane receptor. It contains 3 extracellular cysteine-rich motifs. CD134 is mainly expressed in activated lymphocytes. After interaction with its ligand CD134L (OX40L), CD134 interacts with TNF receptor-associated factor 2 (TRAF2), TRAF5 and mediate activation of nuclear factors NF-κB and AP1. CD134-CD134L have been reported to be involved in T cell selection, migration and induction of Th1 and Th2 cytokine pattern. Moreover, it is involved in anti-tumor immunity, cell adhesion and various auto-immune diseases. Historical data has shown that CD134 receptor blocks T cell proliferation induced by CD134L.

ALTnames :

OX40, TNFRSF 4

Specificity :

Binds human and mouse CD134L (OX40L).

Purity :

≥95% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS.

Uses :

ELISA: binds to CD134L). Can be used together with anti-human IgG1 PAb to detect membrane-bound human CD134L. Has been used to ameliorate graft-versus-host disease, experimental allergic encephalomyelitis and inflammatory bowel disease.

Application Summary :

ELISA

Storage :

-20°C