RANKL (soluble) (human), (recombinant) | Enzo Life Sciences ALX-522-012-C010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

RANKL (soluble) (human), (recombinant)

catalog :

ALX-522-012-C010

quantity :

10 µg

citations: 5

Reference
Seshasayee D, Wang H, Lee W, Gribling P, Ross J, van Bruggen N, et al. A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory response. J Biol Chem. 2004;279:30202-9 pubmed
Zheng B, Georgakis G, Li Y, Bharti A, McConkey D, Aggarwal B, et al. Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors. Clin Cancer Res. 2004;10:3207-15 pubmed
Wittmann M, Kienlin P, Mommert S, Kapp A, Werfel T. Suppression of IL-12 production by soluble CD40 ligand: evidence for involvement of the p44/42 mitogen-activated protein kinase pathway. J Immunol. 2002;168:3793-800 pubmed
Fiumara P, Snell V, Li Y, Mukhopadhyay A, Younes M, Gillenwater A, et al. Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines. Blood. 2001;98:2784-90 pubmed
Collin Osdoby P, Rothe L, Anderson F, Nelson M, Maloney W, Osdoby P. Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis. J Biol Chem. 2001;276:20659-72 pubmed

product information

Product ID :

ALX-522-012

Catalog Number :

ALX-522-012-C010

Product Name :

RANKL (soluble) (human), (recombinant)

Product Type :

Protein

Size :

10 µg

list of Pubmed id :

15145935, 15131062, 11937531, 11675352, 11274143

Image Legend 4 :

Figure 1: Schematic structure of human rhsRANKL (peptide, aa. 151-316).

SPECIES REACTIVITY :

Human, Mouse

Background :

RANK ligand (RANKL), also called TRANCE, OPGL and ODF, is a member of the TNF family that is expressed in activated T cells, lymph nodes and in stromal cell lines. RANKL (TRANCE) interacts with its receptor RANK expressed on mature dendritic cells (DC) and mature osteoclasts, leading to the inhibition of apoptosis, probably through the upregulation of bcl-x. RANKL is, therefore, a useful tool for enhancing DC and osteoclast survival and activity. Osteoprotegerin (OPG, see Prod. No. ALX-522-007) is a potent inhibitor of RANKL. Historical data has shown that the biological activity of RANKL supports the survival of dendritic cells and osteoclasts.

ALTnames :

TRANCE, OPGL, ODF, TNFSF 11, CD254

Specificity :

Binds to human and mouse RANK.

Purity :

≥90% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS.

Uses :

ELISA: binds to RANK receptor.

Application Summary :

ELISA

Storage :

-20°C