TNF-α (soluble) (human), (recombinant) | Enzo Life Sciences ALX-522-008-C050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

TNF-α (soluble) (human), (recombinant)

catalog :

ALX-522-008-C050

quantity :

50 µg

citations: 10

Reference
de Almagro M, Goncharov T, Newton K, Vucic D. Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination. Cell Death Dis. 2015;6:e1800 pubmed publisher
Song Y, Margolles Clark E, BAYER A, Buchwald P. Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction. Br J Pharmacol. 2014;171:4955-69 pubmed publisher
Mahul Mellier A, Datler C, Pazarentzos E, Lin B, Chaisaklert W, Abuali G, et al. De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Biochim Biophys Acta. 2012;1823:1353-65 pubmed publisher
Xue J, Thippegowda P, Hu G, Bachmaier K, Christman J, Malik A, et al. NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene. Physiol Genomics. 2009;38:42-53 pubmed publisher
Riol Blanco L, Sanchez Sanchez N, Torres A, Tejedor A, Narumiya S, Corbi A, et al. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol. 2005;174:4070-80 pubmed
Huard B, Arlettaz L, Ambrose C, Kindler V, Mauri D, Roosnek E, et al. BAFF production by antigen-presenting cells provides T cell co-stimulation. Int Immunol. 2004;16:467-75 pubmed
Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003;114:181-90 pubmed
Klunker S, Trautmann A, Akdis M, Verhagen J, Schmid Grendelmeier P, Blaser K, et al. A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epiderm. J Immunol. 2003;171:1078-84 pubmed
Roehrich M, Mooser V, Lenain V, Herz J, Nimpf J, Azhar S, et al. Insulin-secreting beta-cell dysfunction induced by human lipoproteins. J Biol Chem. 2003;278:18368-75 pubmed
Schneider P, Holler N, Bodmer J, Hahne M, Frei K, Fontana A, et al. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med. 1998;187:1205-13 pubmed

product information

Product ID :

ALX-522-008

Catalog Number :

ALX-522-008-C050

Product Name :

TNF-α (soluble) (human), (recombinant)

Product Type :

Protein

Size :

50 µg

list of Pubmed id :

26111062, 24930776, 22659130, 19351910, 15778365, 14978020, 12887920, 12847282, 12594227, 9547332

SPECIES REACTIVITY :

Human, Mouse

ALTnames :

Tumor necrosis factor-α, TNFSF 2

Specificity :

Binds to human and mouse TNF-R1 and less efficiently to TNF-R2. In the presence of cross-linking enhancer (Prod. No. ALX-804-034), TNF-α shows a significantly higher affinity for TNF-R2 than for TNF-R1, mimicking the characteristics of membrane-bound TNF-α.

Purity :

≥95% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS.

Uses :

ELISA: binds to TNF-R2 at 0.1-10 ng.

Application Summary :

ELISA

Storage :

-20°C