TRAIL (soluble) (human), (recombinant) | Enzo Life Sciences ALX-522-003-C010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

TRAIL (soluble) (human), (recombinant)

catalog :

ALX-522-003-C010

quantity :

10 µg

citations: 11

Reference
Fassl A, Tagscherer K, Richter J, De Castro Arce J, Savini C, RÃ¶sl F, et al. Inhibition of Notch1 signaling overcomes resistance to the death ligand Trail by specificity protein 1-dependent upregulation of death receptor 5. Cell Death Dis. 2015;6:e1921 pubmed publisher
Cazanave S, Mott J, Bronk S, Werneburg N, Fingas C, Meng X, et al. Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J Biol Chem. 2011;286:39336-48 pubmed publisher
Zhang H, Rosenberg S, Coffey F, He Y, Manser T, Hardy R, et al. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol. 2009;182:207-15 pubmed
Meslin F, Hamai A, Gao P, Jalil A, Cahuzac N, Chouaib S, et al. Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death. Cancer Res. 2007;67:10910-9 pubmed
Gajate C, Mollinedo F. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005;280:11641-7 pubmed
Siegmund D, Hausser A, Peters N, Scheurich P, Wajant H. Tumor necrosis factor (TNF) and phorbol ester induce TNF-related apoptosis-inducing ligand (TRAIL) under critical involvement of NF-kappa B essential modulator (NEMO)/IKKgamma. J Biol Chem. 2001;276:43708-12 pubmed
Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J. NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol. 2001;21:5299-305 pubmed
Basile J, Zacny V, Munger K. The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein. J Biol Chem. 2001;276:22522-8 pubmed
Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 2000;1:489-95 pubmed
Sprick M, Weigand M, Rieser E, Rauch C, Juo P, Blenis J, et al. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity. 2000;12:599-609 pubmed
Chinnaiyan A, Prasad U, Shankar S, Hamstra D, Shanaiah M, Chenevert T, et al. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci U S A. 2000;97:1754-9 pubmed

product information

Product ID :

ALX-522-003

Catalog Number :

ALX-522-003-C010

Product Name :

TRAIL (soluble) (human), (recombinant)

Product Type :

Protein

Size :

10 µg

list of Pubmed id :

26469969, 21941003, 19109151, 15659383, 11557763, 11463813, 11306566, 11101870, 10894160, 10677530

SPECIES REACTIVITY :

Human, Mouse

ALTnames :

Apo-2L, TNFSF 10, CD253

Specificity :

Binds to human and mouse TRAIL receptors and human osteoprotegerin (OPG).

Purity :

≥90% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS.

Uses :

ELISA: binds to human TRAIL receptors and human osteoprotegerin (OPG) at 10-100 ng/ml.

Application Summary :

ELISA

Storage :

-20°C