This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Fludarabine
catalog :
ALX-480-100-M025
quantity :
25 mg
citations: 7
Reference
Pepper C, Lowe H, Fegan C, Thurieau C, Thurston D, Hartley J, et al. Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells. Br J Cancer. 2007;97:253-9 pubmed
Nishioka C, Ikezoe T, Yang J, Koeffler H, Taguchi H. Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway. Leukemia. 2007;21:1044-9 pubmed
Montillo M, Ricci F, Tedeschi A. Role of fludarabine in hematological malignancies. Expert Rev Anticancer Ther. 2006;6:1141-61 pubmed
Huang P, Sandoval A, Van den Neste E, Keating M, Plunkett W. Inhibition of RNA transcription: a biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine. Leukemia. 2000;14:1405-13 pubmed
Keating M, Kantarjian H, Talpaz M, Redman J, Koller C, Barlogie B, et al. Fludarabine: a new agent with major activity against chronic lymphocytic leukemia. Blood. 1989;74:19-25 pubmed
Huang P, Plunkett W. Action of 9-beta-D-arabinofuranosyl-2-fluoroadenine on RNA metabolism. Mol Pharmacol. 1991;39:449-55 pubmed
Huang P, Chubb S, Plunkett W. Termination of DNA synthesis by 9-beta-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity. J Biol Chem. 1990;265:16617-25 pubmed
product information
Product ID :
ALX-480-100
Catalog Number :
ALX-480-100-M025
Product Name :
Fludarabine
Product Type :
Biochemical
Size :
25 mg
list of Pubmed id :
17579621, 17344917, 17020450, 10942236, 2473795, 1708088, 1697861
Product Description :
Prodrug converted to the free nucleoside 9-β-D-arabinosyl-2-fluoroadenine (F-ara-A). F-ara-A enters cells and accumulates as the 5'-triphosphate. Interferes with DNA synthesis and repair. Induces apoptosis of cancer cells. Inhibits RNA transcription.
ALTnames :
2-Fluoroadenine-9-β-D-arabinofuranoside
Purity :
≥98% (HPLC)
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.