8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate . sodium salt | Enzo Life Sciences ALX-480-093-M001 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate . sodium salt

catalog :

ALX-480-093-M001

quantity :

1 mg

citations: 3

Reference
Rangarajan S, Enserink J, Kuiperij H, de Rooij J, Price L, Schwede F, et al. Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. J Cell Biol. 2003;160:487-93 pubmed
Kang G, Joseph J, Chepurny O, Monaco M, Wheeler M, Bos J, et al. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem. 2003;278:8279-85 pubmed
Enserink J, Christensen A, de Rooij J, van Triest M, Schwede F, Genieser H, et al. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol. 2002;4:901-6 pubmed

product information

Product ID :

ALX-480-093

Catalog Number :

ALX-480-093-M001

Product Name :

8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate . sodium salt

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

12578910, 12496249, 12402047

Product Description :

Specific, potent and membrane permeant activator of the Epac cAMP receptor. Activates Epac1 and Epac2, the guanine nucleotide-exchange factors (GEFs) for the small GTPases Rap1 and Rap2. Does not activate protein kinase A (PKA), neither in vitro nor in vivo and is therefore a valuable tool to specifically discriminate between PKA- and Epac-mediated effects. Since a free 2'-ribose hydroxyl group in cyclic AMP is essential for stimulation of PKA, the methylated structure of 8-CPT-2'-O-Me-cAMP is an extremely poor PKA activator. Its high lipophilicity allows for good membrane permeability in most biosystems and its increased resistance towards phosphodiesterases prevents rapid hydrolysis.

ALTnames :

8-CPT-2'-O-Me-cAMP . Na

Purity :

≥98% (HPLC)

Storage :

-20°C