Menadione | Enzo Life Sciences ALX-460-007-G010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Menadione

catalog :

ALX-460-007-G010

quantity :

10 g

citations: 9

Reference
Jafari A, Zahmatkesh M, Sadeghipour H, Kajbafzadeh A, Sarrafnejd A, Shahrestany T, et al. Flow cytometric evaluation of sperm superoxide anion production in rats with experimental varicocele. Urology. 2010;75:217-22 pubmed publisher
Kumar S, Malachowski W, DuHadaway J, LaLonde J, Carroll P, Jaller D, et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008;51:1706-18 pubmed publisher
Criddle D, Gillies S, Baumgartner Wilson H, Jaffar M, Chinje E, Passmore S, et al. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. J Biol Chem. 2006;281:40485-92 pubmed
Mauzeroll J, Bard A, Owhadian O, Monks T. Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy. Proc Natl Acad Sci U S A. 2004;101:17582-7 pubmed
Klotz L, Patak P, Ale Agha N, Buchczyk D, Abdelmohsen K, Gerber P, et al. 2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade. Cancer Res. 2002;62:4922-8 pubmed
Okayasu H, Ishihara M, Satoh K, Sakagami H. Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines. Anticancer Res. 2001;21:2387-92 pubmed
Sun L, Yoshii Y, Miyagi K. Cytotoxic effect through fas/APO-1 expression due to vitamin K in human glioma cells. J Neurooncol. 2000;47:31-8 pubmed
Sakagami H, Satoh K, Hakeda Y, Kumegawa M. Apoptosis-inducing activity of vitamin C and vitamin K. Cell Mol Biol (Noisy-le-grand). 2000;46:129-43 pubmed
Wu F, Sun T. Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase. Eur J Cancer. 1999;35:1388-93 pubmed

product information

Product ID :

ALX-460-007

Catalog Number :

ALX-460-007-G010

Product Name :

Menadione

Product Type :

Biochemical

Size :

10 g

list of Pubmed id :

19616831, 18318466, 17088248, 15601769, 12208742, 11724297, 10930097, 10726979, 10658532

Product Description :

Cytotoxic in various cell lines. Induces apoptosis via elevation of peroxide and superoxide radical levels. Affects gap-junctional intercellular communication by mediation of tyrosine phosphorylation.Inhibitor of indoleamine 2,3-dioxygenase (IDO) with an IC50 of ~1µM.

ALTnames :

Vitamin K3, 2-Methyl-1,4-naphthoquinone

Purity :

≥98% (HPLC)

Storage :

Ambient