This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Ionomycin (free acid)
catalog :
ALX-450-006-M001
quantity :
1 mg
citations: 10
Reference
Zhang K, Ge Z, Xue Z, Huang W, Mei M, Zhang Q, et al. Chrysin suppresses human CD14(+) monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol. 2015;288:13-20 pubmed publisher
Rui K, Zhang Z, Tian J, Lin X, Wang X, Ma J, et al. Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis. Cell Mol Immunol. 2016;13:401-8 pubmed publisher
Zhang F, Wang Z, Li M, Lan Y, Chen Y, Wang C. Puerarin attenuates smoke inhalation injury by regulation of Th1/Th2 expression and inhibition of Th17 cells in rats. Int Immunopharmacol. 2015;28:546-53 pubmed publisher
Tian T, Yu S, Liu L, Xue F, Yuan C, Wang M, et al. The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations. PLoS ONE. 2015;10:e0131761 pubmed publisher
Park C, Hahm E, Lee J, Jung K, Rhee H, Yang C. Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line. Carcinogenesis. 2005;26:1929-33 pubmed
Sreedhar A, Srinivas U. Activation of stress response by ionomycin in rat hepatoma cells. J Cell Biochem. 2002;86:154-61 pubmed
Dupuy d Angeac A, Reme T, Monier S, Gao Q, Duperray C, Jullien P, et al. Contrasting effect of transforming growth factor type beta 1 (TGF-beta 1) on proliferation and interleukin-2 receptor expression in activated and rapidly cycling immature (CD3-CD4-CD8-) thymocytes. J Cell Physiol. 1993;154:44-52 pubmed
Lee H. Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose. J Biol Chem. 1993;268:293-9 pubmed
Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation. Science. 1995;267:1485-8 pubmed
Aagaard Tillery K, Jelinek D. Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis. J Immunol. 1995;155:3297-307 pubmed
product information
Product ID :
ALX-450-006
Catalog Number :
ALX-450-006-M001
Product Name :
Ionomycin (free acid)
Product Type :
Biochemical
Size :
1 mg
list of Pubmed id :
26531689, 26388237, 26218281, 26134277, 15930030, 12112026, 8419406, 8416936, 7878466, 7561022
Product Description :
Potent and highly selective calcium ionophore. Ca2+/ionomycin complex forms between pH 7-9.5 which has intense UV absorption. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase. Useful tool for increasing intracellular Ca2+ concentration. More effective than A23187. Non fluorescent. Has been used at 4nM and 2-4µM  (whole cells).
Purity :
≥90% (HPLC, TLC)
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.