Methotrexate | Enzo Life Sciences ALX-440-045-G001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Methotrexate

catalog :

ALX-440-045-G001

quantity :

1 g

citations: 9

Reference
Cutolo M, Bisso A, Sulli A, Felli L, Briata M, Pizzorni C, et al. Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis. J Rheumatol. 2000;27:2551-7 pubmed
Genestier L, Paillot R, Quemeneur L, Izeradjene K, Revillard J. Mechanisms of action of methotrexate. Immunopharmacology. 2000;47:247-57 pubmed
Fairbanks L, Ruckemann K, Qiu Y, Hawrylowicz C, Richards D, Swaminathan R, et al. Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?. Biochem J. 1999;342 ( Pt 1):143-52 pubmed
Paillot R, Genestier L, Fournel S, Ferraro C, Miossec P, Revillard J. Activation-dependent lymphocyte apoptosis induced by methotrexate. Transplant Proc. 1998;30:2348-50 pubmed
Heenen M, Laporte M, Noel J, De Graef C. Methotrexate induces apoptotic cell death in human keratinocytes. Arch Dermatol Res. 1998;290:240-5 pubmed
Genestier L, Paillot R, Fournel S, Ferraro C, Miossec P, Revillard J. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells. J Clin Invest. 1998;102:322-8 pubmed
Huschtscha L, Bartier W, Ross C, Tattersall M. Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro. Br J Cancer. 1996;73:54-60 pubmed
Richardson V, Littlefield L, Sayer A, Peterson P. Cell-cycle-stage specificity of the methotrexate block as resolved by X-ray-induced chromosome damage. Cytogenet Cell Genet. 1994;66:126-8 pubmed
Pittman S, Strickland D, Ireland C. Polymerization of tubulin in apoptotic cells is not cell cycle dependent. Exp Cell Res. 1994;215:263-72 pubmed

product information

Product ID :

ALX-440-045

Catalog Number :

ALX-440-045-G001

Product Name :

Methotrexate

Product Type :

Biochemical

Size :

1 g

list of Pubmed id :

11093433, 10878292, 10432311, 9723499, 9681674, 9664073, 8554984, 8287684, 7982469

Product Description :

Folic acid antagonist. Potent inhibitor of dihydrofolate reductase. Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.

ALTnames :

(+)-Amethopterin, 4-Amino-10-methylfolic acid, Methylaminopterin, MTX

Purity :

≥98% (HPLC)

Storage :

+4°C