RITA | Enzo Life Sciences ALX-430-151-M001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

RITA

catalog :

ALX-430-151-M001

quantity :

1 mg

citations: 4

Reference
Krajewski M, Ozdowy P, D Silva L, Rothweiler U, Holak T. NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nat Med. 2005;11:1135-6; author reply 1136-7 pubmed
Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef L, Masucci M, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004;10:1321-8 pubmed
Nieves Neira W, Rivera M, Kohlhagen G, Hursey M, Pourquier P, Sausville E, et al. DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999;56:478-84 pubmed
Rivera M, Stinson S, Vistica D, Jorden J, Kenney S, Sausville E. Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism. Biochem Pharmacol. 1999;57:1283-95 pubmed

product information

Product ID :

ALX-430-151

Catalog Number :

ALX-430-151-M001

Product Name :

RITA

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

16270059, 15558054, 10462535, 10230772

Product Description :

Inhibitor of p53/HDM2 interaction. Activator of p53 function in tumors. Potently inhibits the growth of a variety of cancer cell lines in the submicromolar range. It has been suggested that RITA selectively targets cells expressing p53 by other mechanisms than direct binding to the N-terminal domain of p53.

ALTnames :

Reactivation of p53 and Induction of Tumor Cell Apoptosis, 2,5-bis(5-Hydroxymethyl-2-thienyl)furan, NSC652287

Purity :

≥98% (HPLC)

Storage :

-20°C