HA14-1 | Enzo Life Sciences ALX-430-101-M005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

HA14-1

catalog :

ALX-430-101-M005

quantity :

5 mg

citations: 4

Reference
Qin G, Wu L, Liu H, Pang Y, Zhao C, Wu S, et al. Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells. Exp Cell Res. 2015;336:308-17 pubmed publisher
Milella M, Estrov Z, Kornblau S, Carter B, Konopleva M, Tari A, et al. Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. Blood. 2002;99:3461-4 pubmed
Liu D, Huang Z. Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis. Apoptosis. 2001;6:453-62 pubmed
Wang J, Liu D, Zhang Z, Shan S, Han X, Srinivasula S, et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A. 2000;97:7124-9 pubmed

product information

Product ID :

ALX-430-101

Catalog Number :

ALX-430-101-M005

Product Name :

HA14-1

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

26163896, 11964319, 11595835, 10860979

Product Description :

Cell permeable, low molecular weight Bcl-2 ligand. Antagonizes the function of Bcl-2 and induces apoptosis. In HL-60 cells, HA4-1 (50µM and 4h incubation) induced apoptosis of more than 90% of the cells. Apoptosis is blocked by ZVAD-FM. IC50 = ~9µM for competition with Flu-BakBH3 binding to Bcl-2.

ALTnames :

Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Purity :

≥95% (1H-NMR)

Storage :

-20°C