Diacylglycerol Kinase Inhibitor II (R59 949) | Enzo Life Sciences ALX-430-028-M005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Diacylglycerol Kinase Inhibitor II (R59 949)

catalog :

ALX-430-028-M005

quantity :

5 mg

citations: 3

Reference
Depeille P, Henricks L, van de Ven R, Lemmens E, Wang C, Matli M, et al. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol. 2015;17:804-15 pubmed publisher
de Chaffoy de Courcelles D, Roevens P, Van Belle H. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. J Biol Chem. 1985;260:15762-70 pubmed
de Chaffoy de Courcelles D, Roevens P, Van Belle H, Kennis L, Somers Y, De Clerck F. The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R 59 949. J Biol Chem. 1989;264:3274-85 pubmed

product information

Product ID :

ALX-430-028

Catalog Number :

ALX-430-028-M005

Product Name :

Diacylglycerol Kinase Inhibitor II (R59 949)

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

26005835, 2999135, 2536741

Product Description :

Inhibitor of diacylglycerol kinase in intact cells (IC50=0.12µM) and in isolated membranes (IC50=0.3µM). More potent analog of R59 022 (Prod. No. ALX-430-027). Useful for elucidating roles of protein kinase C (PKC).

ALTnames :

3-[2-[4-[bis(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

Purity :

≥98% (HPLC)

Storage :

+4°C