This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Purmorphamine
catalog :
ALX-420-045-M001
quantity :
1 mg
citations: 6
Reference
Ehrlich M, Hallmann A, Reinhardt P, Araúzo Bravo M, Korr S, Röpke A, et al. Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein. Stem Cell Reports. 2015;5:83-96 pubmed publisher
Figeac F, Dagouassat M, Mahrouf Yorgov M, le Gouvello S, Trébeau C, Sayed A, et al. Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway. PLoS ONE. 2015;10:e0121579 pubmed publisher
Sinha S, Chen J. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006;2:29-30 pubmed
Beloti M, Bellesini L, Rosa A. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int. 2005;29:537-41 pubmed
Wu X, Walker J, Zhang J, Ding S, Schultz P. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol. 2004;11:1229-38 pubmed
Wu X, Ding S, Ding Q, Gray N, Schultz P. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J Am Chem Soc. 2002;124:14520-1 pubmed
product information
Product ID :
ALX-420-045
Catalog Number :
ALX-420-045-M001
Product Name :
Purmorphamine
Product Type :
Biochemical
Size :
1 mg
list of Pubmed id :
26143746, 25815884, 16408088, 15979909, 15380183, 12465946
Product Description :
Cell permeable purine compound. Induces osteoblast differentiation. Agonist of smoothened by activation of the Hedgehog (Hh) pathway. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Binds to and activates 7-transmembrane receptor of Hh.
ALTnames :
2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Purity :
≥98% (HPLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.