This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
R-848
catalog :
ALX-420-038-M025
quantity :
25 mg
citations: 15
Reference
Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol. 2016;17:250-8 pubmed publisher
Schully K, Bell M, Prouty A, Gallovic M, Gautam S, Peine K, et al. Evaluation of a biodegradable microparticulate polymer as a carrier for Burkholderia pseudomallei subunit vaccines in a mouse model of melioidosis. Int J Pharm. 2015;495:849-61 pubmed publisher
You M, Dong G, Li F, Ma F, Ren J, Xu Y, et al. Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells. Cell Mol Immunol. 2017;14:192-202 pubmed publisher
Ren D, Liu F, Dong G, You M, Ji J, Huang Y, et al. Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus. Cell Mol Immunol. 2016;13:764-775 pubmed publisher
Xiong D, Song L, Zhai X, Geng S, Pan Z, Jiao X. A porcine reproductive and respiratory syndrome virus (PRRSV) vaccine candidate based on the fusion protein of PRRSV glycoprotein 5 and the Toll-like Receptor-5 agonist Salmonella Typhimurium FljB. BMC Vet Res. 2015;11:121 pubmed publisher
Xiong D, Song L, Pan Z, Chen X, Geng S, Jiao X. Identification and immune functional characterization of pigeon TLR7. Int J Mol Sci. 2015;16:8364-81 pubmed publisher
Boltjes A, Groothuismink Z, van Oord G, Janssen H, Woltman A, Boonstra A. Monocytes from chronic HBV patients react in vitro to HBsAg and TLR by producing cytokines irrespective of stage of disease. PLoS ONE. 2014;9:e97006 pubmed publisher
Rovituso D, Heller S, Schroeter M, Kleinschnitz C, Kuerten S. B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients. J Neuroimmunol. 2014;272:86-90 pubmed publisher
Singer B, Opp L, Heinrich A, Schreiber F, Binding Liermann R, Berrocal Almanza L, et al. Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses. PLoS ONE. 2014;9:e94106 pubmed publisher
Festuccia W, Pouliot P, Bakan I, Sabatini D, Laplante M. Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS ONE. 2014;9:e95432 pubmed publisher
Ilyinskii P, Roy C, O Neil C, Browning E, Pittet L, Altreuter D, et al. Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine. 2014;32:2882-95 pubmed publisher
Garbati M, Hays L, Keeble W, Yates J, Rathbun R, Bagby G. FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1? in macrophages. Blood. 2013;122:3197-205 pubmed publisher
Hirai T, Kanda T, Sato K, Takaishi M, Nakajima K, Yamamoto M, et al. Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation. J Immunol. 2013;190:4805-11 pubmed publisher
Anguille S, Lion E, Tel J, de Vries I, Couderé K, Fromm P, et al. Interleukin-15-induced CD56(+) myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential. PLoS ONE. 2012;7:e51851 pubmed publisher
Kwissa M, Nakaya H, Oluoch H, Pulendran B. Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates. Blood. 2012;119:2044-55 pubmed publisher
product information
Product ID :
ALX-420-038
Catalog Number :
ALX-420-038-M025
Product Name :
R-848
Product Type :
Biochemical
Size :
25 mg
list of Pubmed id :
26642356, 26428631, 26277892, 26144250, 26001608, 25874762, 24824830, 24814390, 24743304, 24740015
Product Description :
R-848 is a selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Potent antitumor and antiviral compound. Stimulates antibody secretion, cytokine production, protection from apoptosis and CD80 upregulation.
ALTnames :
4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol, S 28463, Resiquimod
Purity :
≥98% (HPLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.