Cisplatin | Enzo Life Sciences ALX-400-040-M250 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Cisplatin

catalog :

ALX-400-040-M250

quantity :

250 mg

citations: 12

Reference
Sen N, Mukherjee G, Arvin A. Single cell mass cytometry reveals remodeling of human T cell phenotypes by varicella zoster virus. Methods. 2015;90:85-94 pubmed publisher
Andrei A, Hall A, Smith A, BascuÃ±ana C, Malina A, Connor A, et al. Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673. Cancer Lett. 2015;364:8-16 pubmed publisher
Jia J, Bosley A, Thompson A, Hoskins J, Cheuk A, Collins I, et al. CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells. Cancer Res. 2014;74:2785-95 pubmed publisher
Fienberg H, Simonds E, Fantl W, Nolan G, Bodenmiller B. A platinum-based covalent viability reagent for single-cell mass cytometry. Cytometry A. 2012;81:467-75 pubmed publisher
Strieth S, Eichhorn M, Werner A, Sauer B, Teifel M, Michaelis U, et al. Paclitaxel encapsulated in cationic liposomes increases tumor microvessel leakiness and improves therapeutic efficacy in combination with Cisplatin. Clin Cancer Res. 2008;14:4603-11 pubmed publisher
Qamar L, Davis R, Anwar A, Behbakht K. Protein kinase C inhibitor Gö6976 augments caffeine-induced reversal of chemoresistance to cis-diamminedichloroplatinum-II (CDDP) in a human ovarian cancer model. Gynecol Oncol. 2008;110:425-31 pubmed publisher
Xiao L, Lu X, Ruden D. Effectiveness of hsp90 inhibitors as anti-cancer drugs. Mini Rev Med Chem. 2006;6:1137-43 pubmed
van Waardenburg R, de Jong L, van Eijndhoven M, Verseyden C, Pluim D, Jansen L, et al. Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin. J Biol Chem. 2004;279:54502-9 pubmed
Siddik Z. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene. 2003;22:7265-79 pubmed
Bose R. Biomolecular targets for platinum antitumor drugs. Mini Rev Med Chem. 2002;2:103-11 pubmed
Seki K, Yoshikawa H, Shiiki K, Hamada Y, Akamatsu N, Tasaka K. Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. Cancer Chemother Pharmacol. 2000;45:199-206 pubmed
Razzaque M, Koji T, Kumatori A, Taguchi T. Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand system. Histochem Cell Biol. 1999;111:359-65 pubmed

product information

Product ID :

ALX-400-040

Catalog Number :

ALX-400-040-M250

Product Name :

Cisplatin

Product Type :

Biochemical

Size :

250 mg

list of Pubmed id :

26213183, 25864590, 18628475, 18619662, 17073714, 15471886, 14576837, 12370072, 10663637, 10403114

Product Description :

A potent platinum-based antineoplastic drug. Its mode of action involves formation of inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I. Cisplatin synergizes with a variety of anticancer agents. Tumor cells rapidly develop resistance to cisplatin and numerous agents are available to block or reverse resistance.

ALTnames :

cis-Platinum(ll)diamine dichloride

Purity :

≥98% (Assay)

Storage :

Ambient