Aurodox | Enzo Life Sciences ALX-380-314-MM25 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Aurodox

catalog :

ALX-380-314-MM25

quantity :

2.5 mg

citations: 6

Reference
Vogeley L, Palm G, Mesters J, Hilgenfeld R. Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodox. J Biol Chem. 2001;276:17149-55 pubmed publisher
Bhuta P, CHLADEK S. Stimulation of Escherichia coli elongation factor Tu-dependent GTP hydrolysis by aminoacyl oligonucleotides in the presence of aurodox. FEBS Lett. 1980;122:113-6 pubmed
Chinali G. Synthetic analogs of aurodox and kirromycin active on elongation factor Tu from Escherichia coli. J Antibiot (Tokyo). 1981;34:1039-45 pubmed
Dell V, Miller D, Johnson A. Effects of nucleotide- and aurodox-induced changes in elongation factor Tu conformation upon its interactions with aminoacyl transfer RNA. A fluorescence study. Biochemistry. 1990;29:1757-63 pubmed
Liu C, Hermann T, Miller P. Feedback inhibition of the synthesis of an antibiotic: aurodox (X-5108). J Antibiot (Tokyo). 1977;30:244-51 pubmed
Unowsky J, Hoppe D. Increased production of the antibiotic aurodox (X-5108) by aurodox-resistant mutants. J Antibiot (Tokyo). 1978;31:662-6 pubmed

product information

Product ID :

ALX-380-314

Catalog Number :

ALX-380-314-MM25

Product Name :

Aurodox

Product Type :

Biochemical

Size :

2.5 mg

list of Pubmed id :

11278992, 6783438, 6119303, 2110000, 405357, 357362

Product Description :

Inhibits bacterial protein biosynthesis by interrupting the functional cycle of Elongation Factor-Tu (EF-Tu). Weakly acidic. pKa = 6.1.

Background :

Aurodox is the N-methyl derivative of kirromycin. Aurodox has been shown to interfere with the role of bacterial elongation factor Tu (EF-Tu) in protein biosynthesis: Like kirromycin, aurodox interrupts the functional cycle of EF-Tu by inhibiting the release of the EF-Tu·GDP complex from the ribosome, thus provoking stalled ribosomes that cause a polysomal traffic jam on the mRNA. The crystal structure of the complex between EF-Tu.GDP and aurodox has been elucidated and provided substantial insights into the molecular mechanisms underlying the antibotic activity of aurodox.

ALTnames :

1-Methylmocimycin, X 5108, Goldinodox, (αS,2R,3R,4R,6S)-N-[(2E,4E,6S,7R)-7-[(2S,3S,4R,5R)-5-[(1E,3E,5E)-7-(1,2-Dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrien-1-yl]tetrahydro-3,4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2,4-octadien-1-yl]-α-ethyltetrahydro-2,3,4-trihydroxy-5,5-dimethyl-6-(1E,3Z)-1,3-pentadien-1-yl-2H-pyran-2-acetamide

Purity :

≥95% (HPLC)

Storage :

-20°C