Cycloheximide | Enzo Life Sciences ALX-380-269-G001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Cycloheximide

catalog :

ALX-380-269-G001

quantity :

1 g

citations: 10

Reference
Li K, Guo E, Hossain M, Li Q, Cao Y, Tian L, et al. Bombyx E75 isoforms display stage- and tissue-specific responses to 20-hydroxyecdysone. Sci Rep. 2015;5:12114 pubmed publisher
Christner C, Wyrwa R, Marsch S, Küllertz G, Thiericke R, Grabley S, et al. Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J Med Chem. 1999;42:3615-22 pubmed
Lemaire C, Andreau K, Souvannavong V, Adam A. Specific dual effect of cycloheximide on B lymphocyte apoptosis: involvement of CPP32/caspase-3. Biochem Pharmacol. 1999;58:85-93 pubmed
Lu Q, Mellgren R. Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells. Arch Biochem Biophys. 1996;334:175-81 pubmed
Aten J, Prigent P, Poncet P, Blanpied C, Claessen N, Druet P, et al. Mercuric chloride-induced programmed cell death of a murine T cell hybridoma. I. Effect of the proto-oncogene Bcl-2. Cell Immunol. 1995;161:98-106 pubmed
Chow S, Peters I, Orrenius S. Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis. Exp Cell Res. 1995;216:149-59 pubmed
Grand R, Milner A, Mustoe T, Johnson G, Owen D, Grant M, et al. A novel protein expressed in mammalian cells undergoing apoptosis. Exp Cell Res. 1995;218:439-51 pubmed
Lotem J, Sachs L. Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone. Cell Growth Differ. 1995;6:647-53 pubmed
Obrig T, Culp W, McKeehan W, Hardesty B. The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. J Biol Chem. 1971;246:174-81 pubmed
Widelitz R, Magun B, Gerner E. Effects of cycloheximide on thermotolerance expression, heat shock protein synthesis, and heat shock protein mRNA accumulation in rat fibroblasts. Mol Cell Biol. 1986;6:1088-94 pubmed

product information

Product ID :

ALX-380-269

Catalog Number :

ALX-380-269-G001

Product Name :

Cycloheximide

Product Type :

Biochemical

Size :

1 g

list of Pubmed id :

26166384, 10479292, 10403522, 8837753, 7867088, 7813615, 7796880, 7669718, 5541758, 3785158

Product Description :

Antibiotic. Inhibits protein synthesis in eukaryotes by interfering with the translocation step. Induces apoptosis in tumor cell lines but can also delay or inhibit apoptosis induced by other agents. Widely used for selection of resistant strains of yeast and fungy, controlled inhibiton of protein synthesis for detecton of short-lived proteins and super-induction of protein expression. At 10µg/ml cycloheximide totally inhibits protein synthesis in mouse thymocytes.

ALTnames :

Actidione, Naramycin A, 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide

Purity :

≥95% (TLC)

Storage :

-20°C