Thiostrepton | Enzo Life Sciences ALX-380-261-G005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Thiostrepton

catalog :

ALX-380-261-G005

quantity :

5 g

citations: 10

Reference
García Marcos A, Morreale A, Guarinos E, Briones E, Remacha M, Ortiz A, et al. In vivo assembling of bacterial ribosomal protein L11 into yeast ribosomes makes the particles sensitive to the prokaryotic specific antibiotic thiostrepton. Nucleic Acids Res. 2007;35:7109-17 pubmed
Bausch S, Poliakova E, Draper D. Interactions of the N-terminal domain of ribosomal protein L11 with thiostrepton and rRNA. J Biol Chem. 2005;280:29956-63 pubmed
Bowen W, Van Dyke N, Murgola E, Lodmell J, Hill W. Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain. J Biol Chem. 2005;280:2934-43 pubmed
Rodnina M, Savelsbergh A, Matassova N, Katunin V, Semenkov Y, Wintermeyer W. Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc Natl Acad Sci U S A. 1999;96:9586-90 pubmed
Rosendahl G, Douthwaite S. The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A. Nucleic Acids Res. 1994;22:357-63 pubmed
Bodley J, Lin L, Highland J. Studies on translocation. VI. Thiostrepton prevents the formation of a ribosome-G factor-guanine nucleotide complex. Biochem Biophys Res Commun. 1970;41:1406-11 pubmed
Kutay U, Spahn C, Nierhaus K. Similarities and differences in the inhibition patterns of thiostrepton and viomycin: evidence for two functionally different populations of P sites when occupied with AcPhe-tRNA. Biochim Biophys Acta. 1990;1050:193-6 pubmed
Miller S, Bodley J. Alpha-sarcin cleavage of ribosomal RNA is inhibited by the binding of elongation factor G or thiostrepton to the ribosome. Nucleic Acids Res. 1991;19:1657-60 pubmed
Ryan P, Lu M, Draper D. Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton. J Mol Biol. 1991;221:1257-68 pubmed
Malina H, Robert Gero M. Characterization of an 8.7-kilobase thiostrepton resistance-encoding plasmid (pGIF3) of Streptomyces incarnatus. Appl Environ Microbiol. 1992;58:895-9 pubmed

product information

Product ID :

ALX-380-261

Catalog Number :

ALX-380-261-G005

Product Name :

Thiostrepton

Product Type :

Biochemical

Size :

5 g

list of Pubmed id :

17940088, 15972821, 15492007, 10449736, 8127673, 5487868, 2169893, 2027773, 1942050, 1575490

Product Description :

Thiazole-containing peptide antibiotic. Inhibits protein synthesis by preventing binding of GTP to the 50S ribosomal subunit. Inhibits binding of elongation factor G (EF-G) and the dissociation of EF-G from the ribosome.

Purity :

≥95% (HPLC)

Storage :

-20°C