Echinomycin | Enzo Life Sciences ALX-380-201-M001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Echinomycin

catalog :

ALX-380-201-M001

quantity :

1 mg

citations: 10

Reference
Kuphal S, Winklmeier A, Warnecke C, Bosserhoff A. Constitutive HIF-1 activity in malignant melanoma. Eur J Cancer. 2010;46:1159-69 pubmed publisher
Cairns R, Papandreou I, Sutphin P, Denko N. Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy. Proc Natl Acad Sci U S A. 2007;104:9445-50 pubmed
Pacary E, Legros H, Valable S, Duchatelle P, Lecocq M, Petit E, et al. Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells. J Cell Sci. 2006;119:2667-78 pubmed
Park J, Ryang Y, Shim K, Lee J, Kim H, Kim Y, et al. Molecular signaling cascade in DNA bisintercalator, echinomycin-induced apoptosis of HT-29 cells: evidence of the apoptotic process via activation of the cytochrome c-ERK-caspase-3 pathway. Int J Biochem Cell Biol. 2006;38:244-54 pubmed
Kong D, Park E, Stephen A, Calvani M, Cardellina J, Monks A, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005;65:9047-55 pubmed
Park J, Park S, Shim K, Lee K, Kim Y, Kim Y, et al. Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. Pharmacol Res. 2004;50:201-7 pubmed
May L, Madine M, Waring M. Echinomycin inhibits chromosomal DNA replication and embryonic development in vertebrates. Nucleic Acids Res. 2004;32:65-72 pubmed
Leng F, Chaires J, Waring M. Energetics of echinomycin binding to DNA. Nucleic Acids Res. 2003;31:6191-7 pubmed
Katagiri K, Shoji J, YOSHISA T. Identity of levomycin and quinomycin A (echimomycin). J Antibiot (Tokyo). 1962;15:273 pubmed
Bailly C, Gentle D, Hamy F, Purcell M, Waring M. Localized chemical reactivity in DNA associated with the sequence-specific bisintercalation of echinomycin. Biochem J. 1994;300 ( Pt 1):165-73 pubmed

product information

Product ID :

ALX-380-201

Catalog Number :

ALX-380-201-M001

Product Name :

Echinomycin

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

20185296, 17517659, 16772336, 16214385, 16204079, 15177310, 14704344, 14576305, 14042112, 8198530

Product Description :

Antitumor antibiotic. Powerful, selective inhibitor of nucleic acid synthesis in vitro. Potent inhibitor of hypoxia-inducible factor 1 (HIF-1) DNA binding activity. Induces apoptosis. Displays antibacterial, antifungal and antiviral activities.

ALTnames :

Quinomycin A

Purity :

≥98% (HPLC)

Storage :

-20°C