K-252c | Enzo Life Sciences ALX-380-103-M001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

K-252c

catalog :

ALX-380-103-M001

quantity :

1 mg

citations: 10

Reference
Hudkins R, Johnson N, Angeles T, Gessner G, Mallamo J. Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a. J Med Chem. 2007;50:433-41 pubmed
Howard Jones A, Walsh C. Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid. J Am Chem Soc. 2006;128:12289-98 pubmed
Prudhomme M. Biological targets of antitumor indolocarbazoles bearing a sugar moiety. Curr Med Chem Anticancer Agents. 2004;4:509-21 pubmed
McGovern S, Shoichet B. Kinase inhibitors: not just for kinases anymore. J Med Chem. 2003;46:1478-83 pubmed
Pindur U, Kim Y, Mehrabani F. Advances in indolo[2,3-a]carbazole chemistry: design and synthesis of protein kinase C and topoisomerase I inhibitors. Curr Med Chem. 1999;6:29-69 pubmed
Martiny Baron G, Kazanietz M, Mischak H, Blumberg P, Kochs G, Hug H, et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem. 1993;268:9194-7 pubmed
Fabre S, Prudhomme M, Rapp M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg Med Chem. 1993;1:193-6 pubmed
Horton P, Longley R, McConnell O, Ballas L. Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp. Experientia. 1994;50:843-5 pubmed
Omura S, Sasaki Y, Iwai Y, Takeshima H. Staurosporine, a potentially important gift from a microorganism. J Antibiot (Tokyo). 1995;48:535-48 pubmed
Yasuzawa T, Iida T, Yoshida M, Hirayama N, Takahashi M, Shirahata K, et al. The structures of the novel protein kinase C inhibitors K-252a, b, c and d. J Antibiot (Tokyo). 1986;39:1072-8 pubmed

product information

Product ID :

ALX-380-103

Catalog Number :

ALX-380-103-M001

Product Name :

K-252c

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

17266195, 16967980, 15579016, 12672248, 9873114, 8486620, 8081852, 7925852, 7649849, 3759659

Product Description :

Inhibitor of protein kinase C (PKC). Aglycone of staurosporine.

ALTnames :

Staurosporinone, Staurosporine Aglycone

Purity :

≥95% (HPLC)

Storage :

-20°C