Concanamycin A | Enzo Life Sciences ALX-380-034-C025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Concanamycin A

catalog :

ALX-380-034-C025

quantity :

25 µg

citations: 10

Reference
Teixeira V, Medeiros T, VilaÃ§a R, Ferreira J, Moradas Ferreira P, Costa V. Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells. Biochim Biophys Acta. 2016;1861:21-33 pubmed publisher
Dawaliby R, Mayer A. Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions. Mol Biol Cell. 2010;21:4173-83 pubmed publisher
Melki M, Saidi H, Dufour A, Olivo Marin J, Gougeon M. Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1. PLoS Pathog. 2010;6:e1000862 pubmed publisher
Xiong Y, Contento A, Nguyen P, Bassham D. Degradation of oxidized proteins by autophagy during oxidative stress in Arabidopsis. Plant Physiol. 2007;143:291-9 pubmed
Hong J, Nakano Y, Yokomakura A, Ishihara K, Kim S, Kang Y, et al. Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. J Pharmacol Exp Ther. 2006;319:672-81 pubmed
Haydock S, Appleyard A, Mironenko T, Lester J, Scott N, Leadlay P. Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449. Microbiology. 2005;151:3161-9 pubmed
Huss M, Ingenhorst G, König S, Gassel M, Dröse S, Zeeck A, et al. Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c. J Biol Chem. 2002;277:40544-8 pubmed
Yilla M, Tan A, Ito K, Miwa K, Ploegh H. Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells. J Biol Chem. 1993;268:19092-100 pubmed
Muroi M, Takasu A, Yamasaki M, Takatsuki A. Folimycin (concanamycin A), an inhibitor of V-type H(+)-ATPase, blocks cell-surface expression of virus-envelope glycoproteins. Biochem Biophys Res Commun. 1993;193:999-1005 pubmed
Dröse S, Bindseil K, Bowman E, Siebers A, Zeeck A, Altendorf K. Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases. Biochemistry. 1993;32:3902-6 pubmed

product information

Product ID :

ALX-380-034

Catalog Number :

ALX-380-034-C025

Product Name :

Concanamycin A

Product Type :

Biochemical

Size :

25 µg

list of Pubmed id :

26477382, 20943953, 20419158, 17098847, 16895977, 16207901, 12186879, 8395529, 8391816, 8385991

Product Description :

Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1 (Prod. No. BML-CM110). Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production. Inhibits Autophagy.

ALTnames :

Folimycin

Purity :

≥98% (HPLC)

Storage :

-20°C