This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Staurosporine
catalog :
ALX-380-014-C250
quantity :
250 µg
citations: 11
Reference
Qin G, Wu L, Liu H, Pang Y, Zhao C, Wu S, et al. Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells. Exp Cell Res. 2015;336:308-17 pubmed publisher
Ho J, Nadeem A, Rydström A, Puthia M, Svanborg C. Targeting of nucleotide-binding proteins by HAMLET--a conserved tumor cell death mechanism. Oncogene. 2016;35:897-907 pubmed publisher
Mani J, Vallo S, Rakel S, Antonietti P, Gessler F, Blaheta R, et al. Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer. 2015;15:224 pubmed publisher
Pfister A, Keil M, Kühl M. The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway. J Biol Chem. 2015;290:10905-18 pubmed publisher
Bastian A, Thorpe J, Disch B, Bailey Downs L, Gangjee A, Devambatla R, et al. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. J Pharmacol Exp Ther. 2015;353:392-404 pubmed publisher
Swain L, Wottawa M, Hillemann A, Beneke A, Odagiri H, Terada K, et al. Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions. J Leukoc Biol. 2014;96:365-75 pubmed publisher
Kim M, Song K, Jin E, Sonn J. Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way. Exp Mol Med. 2012;44:521-8 pubmed
Daudt D, Yorio T. FKBP51 protects 661w cell culture from staurosporine-induced apoptosis. Mol Vis. 2011;17:1172-81 pubmed
Burugula B, Ganesh B, Chintala S. Curcumin attenuates staurosporine-mediated death of retinal ganglion cells. Invest Ophthalmol Vis Sci. 2011;52:4263-73 pubmed publisher
Thompson A, Levin L. Neuronal differentiation by analogs of staurosporine. Neurochem Int. 2010;56:554-60 pubmed publisher
Goval J, Thielen C, Bourguignon C, Greimers R, Dejardin E, Choi Y, et al. The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP. Haematologica. 2008;93:1169-77 pubmed publisher
product information
Product ID :
ALX-380-014
Catalog Number :
ALX-380-014-C250
Product Name :
Staurosporine
Product Type :
Biochemical
Size :
250 µg
list of Pubmed id :
26163896, 26028028, 25885284, 25759387, 25720766, 24626957, 22684244, 21617754, 21498608, 20043966
Product Description :
Model apoptosis inducer. Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5nM), CDK2/cyclin A (IC50=7nM), CDK4/cyclin D (IC50=3-10µM), CDK5/p25 (IC50=4nM), GSK-3β (IC50=15nM), Pim-1 kinase (IC50=10nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine.
ALTnames :
Antibiotic AM-2282
Purity :
≥99% (HPLC)
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.