This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Streptozotocin
catalog :
ALX-380-010-M100
quantity :
100 mg
citations: 10
Reference
Shi Y, Sun X, Sun Y, Hou L, Yao M, Lian K, et al. Elevation of cortical C26:0 due to the decline of peroxisomal β-oxidation potentiates amyloid β generation and spatial memory deficits via oxidative stress in diabetic rats. Neuroscience. 2016;315:125-35 pubmed publisher
Hadjzadeh M, Rajaei Z, Moradi R, Ghorbani A. Effects of Hydroalcoholic Extract of Watercress (Nasturtium Officinale) Leaves on Serum Glucose and Lipid Levels in Diabetic Rats. Indian J Physiol Pharmacol. 2015;59:223-30 pubmed
Khairoun M, van den Heuvel M, van den Berg B, Sorop O, de Boer R, van Ditzhuijzen N, et al. Early systemic microvascular damage in pigs with atherogenic diabetes mellitus coincides with renal angiopoietin dysbalance. PLoS ONE. 2015;10:e0121555 pubmed publisher
Ibrahim A, Elshafey S, Sellak H, Hussein K, El Sherbiny M, Abdelsaid M, et al. A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase. J Lipid Res. 2015;56:599-611 pubmed publisher
Ibrahim A, Tawfik A, Hussein K, Elshafey S, Markand S, Rizk N, et al. Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids. Biochim Biophys Acta. 2015;1851:290-8 pubmed publisher
Johnston A, Campbell J, Found J, Riddell M, Hawke T. Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo. Am J Physiol Cell Physiol. 2007;292:C1033-40 pubmed
Bolzán A, Bianchi M. Genotoxicity of streptozotocin. Mutat Res. 2002;512:121-34 pubmed
Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 2001;50:537-46 pubmed
Bedoya F, Solano F, Lucas M. N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets. Experientia. 1996;52:344-7 pubmed
Chang K, Chong W, Park B, Seung B, Chun G, Lee I, et al. NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta. Biochem Biophys Res Commun. 1993;191:509-14 pubmed
product information
Product ID :
ALX-380-010
Catalog Number :
ALX-380-010-M100
Product Name :
Streptozotocin
Product Type :
Biochemical
Size :
100 mg
list of Pubmed id :
26687434, 26685512, 25909188, 25598081, 25562624, 17092995, 12464347, 11829314, 8620938, 8461007
Product Description :
Widely used diabetes inducer in rodents. Inhibition of β-cell O-GlcNAcase by streptozotocin is the mechanism that accounts for its diabetogenic toxicity. N-nitroso-containing antibiotic, acting as a nitric oxide (NO) donor and vasorelaxant. Relaxes phenylephrine-contracted aortic rings at 10µM. Potent methylating agent for DNA.
ALTnames :
Streptozocin, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, STZ
Purity :
≥97% (Assay)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.