This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
FK506
catalog :
ALX-380-008-M025
quantity :
25 mg
citations: 10
Reference
Vázquez B, Soto T, del Dedo J, Franco A, Vicente J, Hidalgo E, et al. Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast. Cell Signal. 2015;27:2534-42 pubmed publisher
Koyano Nakagawa N, Shi X, Rasmussen T, Das S, Walter C, Garry D. Feedback Mechanisms Regulate Ets Variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages. J Biol Chem. 2015;290:28107-19 pubmed publisher
Clift D, Thorn R, Passarelli E, Kapoor M, LoPiccolo M, Richendrfer H, et al. Effects of embryonic cyclosporine exposures on brain development and behavior. Behav Brain Res. 2015;282:117-24 pubmed publisher
Miyata S, Ohkubo Y, Mutoh S. A review of the action of tacrolimus (FK506) on experimental models of rheumatoid arthritis. Inflamm Res. 2005;54:1-9 pubmed
Klettner A, Herdegen T. FK506 and its analogs - therapeutic potential for neurological disorders. Curr Drug Targets CNS Neurol Disord. 2003;2:153-62 pubmed
Dumont F. FK506, an immunosuppressant targeting calcineurin function. Curr Med Chem. 2000;7:731-48 pubmed
Zhang Y, Sun X, Muraoka K, Ikeda A, Miyamoto S, Shimizu H, et al. Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites. J Biol Chem. 1999;274:34657-62 pubmed
Bierer B, Hollander G, Fruman D, Burakoff S. Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. Curr Opin Immunol. 1993;5:763-73 pubmed
Kunz J, Hall M. Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. Trends Biochem Sci. 1993;18:334-8 pubmed
Kino T, Hatanaka H, Hashimoto M, Nishiyama M, Goto T, Okuhara M, et al. FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1987;40:1249-55 pubmed
product information
Product ID :
ALX-380-008
Catalog Number :
ALX-380-008-M025
Product Name :
FK506
Product Type :
Biochemical
Size :
25 mg
list of Pubmed id :
26432170, 26396195, 25591474, 15723198, 12769796, 10702636, 10574930, 7694595, 7694398, 2445721
Product Description :
Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK506 binding protein and to inhibit the Ca2+-dependent phosphatase and protein phosphatase 2B (PP2B; calcineurin). Activates NF-κB through phosphorylation and degradation of IκBα.
ALTnames :
Tacrolimus
Purity :
≥98% (Assay)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.