Rotenone | Enzo Life Sciences ALX-350-360-G005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Rotenone

catalog :

ALX-350-360-G005

quantity :

5 g

citations: 10

Reference
Marella M, Seo B, Nakamaru Ogiso E, Greenamyre J, Matsuno Yagi A, Yagi T. Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease. PLoS ONE. 2008;3:e1433 pubmed publisher
Jin J, Davis J, Zhu D, Kashima D, Leroueil M, Pan C, et al. Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells. BMC Neurosci. 2007;8:67 pubmed
Srivastava P, Panda D. Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding. FEBS J. 2007;274:4788-801 pubmed
Jiang Q, Yan Z, Feng J. Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons. J Biol Chem. 2006;281:29391-400 pubmed
Wood D, Alsahaf H, Streete P, Dargan P, Jones A. Fatality after deliberate ingestion of the pesticide rotenone: a case report. Crit Care. 2005;9:R280-4 pubmed
Testa C, Sherer T, Greenamyre J. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Res Mol Brain Res. 2005;134:109-18 pubmed
Cassarino D, Parks J, Parker W, Bennett J. The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochim Biophys Acta. 1999;1453:49-62 pubmed
Higuchi M, Proske R, Yeh E. Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis. Oncogene. 1998;17:2515-24 pubmed
Higgins D, Greenamyre J. [3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study. J Neurosci. 1996;16:3807-16 pubmed
Fukami J, Yamamoto I, Casida J. Metabolism of rotenone in vitro by tissue homogenates from mammals and insects. Science. 1967;155:713-6 pubmed

product information

Product ID :

ALX-350-360

Catalog Number :

ALX-350-360-G005

Product Name :

Rotenone

Product Type :

Biochemical

Size :

5 g

list of Pubmed id :

18197244, 17705834, 17697112, 16887804, 15987402, 15790535, 9989245, 9824162, 8656275, 4381128

Product Description :

Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC50=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding. Can inhibit mitochondrial swelling and cytochrome c release induced by N-methyl-4-phenylpyridinium.

Purity :

≥98% (UHPLC)

Storage :

-20°C