10Z-Hymenialdisine | Enzo Life Sciences ALX-350-289-M001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

10Z-Hymenialdisine

catalog :

ALX-350-289-M001

quantity :

1 mg

citations: 10

Reference
Sharma V, Lansdell T, Jin G, Tepe J. Inhibition of cytokine production by hymenialdisine derivatives. J Med Chem. 2004;47:3700-3 pubmed
Biernat J, Wu Y, Timm T, Zheng Fischhöfer Q, Mandelkow E, Meijer L, et al. Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell. 2002;13:4013-28 pubmed
Tasdemir D, Mallon R, Greenstein M, Feldberg L, Kim S, Collins K, et al. Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002;45:529-32 pubmed
Inoue H, Takamori M, Nagata N, Nishikawa T, Oda H, Yamamoto S, et al. An investigation of cell proliferation and soluble mediators induced by interleukin 1beta in human synovial fibroblasts: comparative response in osteoarthritis and rheumatoid arthritis. Inflamm Res. 2001;50:65-72 pubmed
Curman D, Cinel B, Williams D, Rundle N, Block W, Goodarzi A, et al. Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. J Biol Chem. 2001;276:17914-9 pubmed
Meijer L, Thunnissen A, White A, Garnier M, Nikolic M, Tsai L, et al. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem Biol. 2000;7:51-63 pubmed
Badger A, Cook M, Swift B, Newman Tarr T, Gowen M, Lark M. Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine. J Pharmacol Exp Ther. 1999;290:587-93 pubmed
Roshak A, Jackson J, Chabot Fletcher M, Marshall L. Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine. J Pharmacol Exp Ther. 1997;283:955-61 pubmed
Breton J, Chabot Fletcher M. The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB. J Pharmacol Exp Ther. 1997;282:459-66 pubmed
Supriyono A, Schwarz B, Wray V, Witte L, Muller W, van Soest R, et al. Bioactive alkaloids from the tropical marine sponge Axinella carteri. Z Naturforsch C. 1995;50:669-74 pubmed

product information

Product ID :

ALX-350-289

Catalog Number :

ALX-350-289-M001

Product Name :

10Z-Hymenialdisine

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

15214798, 12429843, 11784156, 11289656, 11279124, 10662688, 10411566, 9353419, 9223588, 8579685

Product Description :

Originally isolated from the sponges Axinella verrucosa and Acantella aurantiaca. Potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC50=6nM). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-β (GSK-3β) and CDK5/p35 in Alzheimer’s disease. Inhibitor of DNA damage checkpoint at G2 phase (IC50=6µM), cyclin-dependent kinases CDK1/cyclin B (IC50=22nM), CDK2/cyclin A (IC50=70nM), CDK2/cyclin E (IC50=40nM), CDK4/cyclin D1 (IC50=600nM), CDK5/p25 (IC50=28nM), GSK-3β (IC50=10nM), and casein kinase 1 (CK1) (IC50=35nM). Inhibitor of NF-κB activation and of various pro-inflammatory cytokines such as IL-1, IL-2 (IC50=2.4µM), IL-6, IL-8, TNF-α (IC50=1.4µM) and nitric oxide (NO) (IC50=0.8µM) in a variety of cell lines.MARK (microtubule affinity-regulating kinase) is potently inhibited by Hymenialdsine. In N2a cells stably transfected with htau40, Hymenialdisine (50µM) strongly inihibted neuritrite outgrowth.

ALTnames :

4-(2-Amino-4-oxo-2-imidazolin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one

Purity :

≥97% (HPLC)

Storage :

-20°C