Triptolide | Enzo Life Sciences ALX-350-259-M001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Triptolide

catalog :

ALX-350-259-M001

quantity :

1 mg

citations: 10

Reference
Sutani T, Sakata T, Nakato R, Masuda K, Ishibashi M, Yamashita D, et al. Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation. Nat Commun. 2015;6:7815 pubmed publisher
Liu L, Jiang Z, Liu J, Huang X, Wang T, Liu J, et al. Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats. Toxicology. 2010;271:57-63 pubmed publisher
Carter B, Mak D, Schober W, McQueen T, Harris D, Estrov Z, et al. Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood. 2006;108:630-7 pubmed
Westerheide S, Kawahara T, Orton K, Morimoto R. Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. J Biol Chem. 2006;281:9616-22 pubmed
Miyata Y, Sato T, Ito A. Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells. Biochem Biophys Res Commun. 2005;336:1081-6 pubmed
Liacini A, Sylvester J, Zafarullah M. Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes. Biochem Biophys Res Commun. 2005;327:320-7 pubmed
Qiu D, Kao P. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D. 2003;4:1-18 pubmed
Chan M, Kohlmeier J, Branden M, Jung M, Benedict S. Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506. Phytother Res. 1999;13:464-7 pubmed
Lee K, Chang W, Qiu D, Kao P, Rosen G. PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells. J Biol Chem. 1999;274:13451-5 pubmed
Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, et al. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J Biol Chem. 1999;274:13443-50 pubmed

product information

Product ID :

ALX-350-259

Catalog Number :

ALX-350-259-M001

Product Name :

Triptolide

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

26204128, 20223271, 16556893, 16469748, 16176806, 15629465, 12568630, 10479754, 10224110, 10224109

Product Description :

Immunosuppressive agent with anti-inflammatory and antitumor properties. More effective in preventing T cell proliferation and interferon-γ production than FK506 (Prod. No. ALX-380-008). Induces apoptosis in T cells by activating DEVD cleaving caspases. Blocks TNF-α mediated induction of c-IAP1 and c-IAP2 and NF-κB activation. Inhibits induction of MMP-3, MMP-13, and ADAMTS-4 in cell culture.

ALTnames :

PG490

Purity :

≥98% (HPLC)

Storage :

-20°C