This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Lactacystin (native)
catalog :
ALX-350-245-MC01
quantity :
0.1 mg
citations: 10
Reference
Yew E, Cheung N, Choy M, Qi R, Lee A, Peng Z, et al. Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis. J Neurochem. 2005;94:943-56 pubmed
Kozlowski L, Stoklosa T, Omura S, Wójcik C, Wojtukiewicz M, Worowski K, et al. Lactacystin inhibits cathepsin A activity in melanoma cell lines. Tumour Biol. 2001;22:211-5 pubmed
Tomoda H, Omura S. Lactacystin, a proteasome inhibitor: discovery and its application in cell biology. Yakugaku Zasshi. 2000;120:935-49 pubmed
Mutomba M, Wang C. The role of proteolysis during differentiation of Trypanosoma brucei from the bloodstream to the procyclic form. Mol Biochem Parasitol. 1998;93:11-22 pubmed
Delic J, Masdehors P, Omura S, Cosset J, Dumont J, Binet J, et al. The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis. Br J Cancer. 1998;77:1103-7 pubmed
Marambaud P, Ancolio K, Lopez Perez E, Checler F. Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells. Mol Med. 1998;4:147-57 pubmed
Fenteany G, Schreiber S. Lactacystin, proteasome function, and cell fate. J Biol Chem. 1998;273:8545-8 pubmed
Miura H, Tomoda H, Miura K, Takishima K, Omura S. Lactacystin increases LDL receptor level on HepG2 cells. Biochem Biophys Res Commun. 1996;227:684-7 pubmed
Blagosklonny M, Wu G, Omura S, El Deiry W. Proteasome-dependent regulation of p21WAF1/CIP1 expression. Biochem Biophys Res Commun. 1996;227:564-9 pubmed
McGee T, Cheng H, Kumagai H, Omura S, Simoni R. Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis. J Biol Chem. 1996;271:25630-8 pubmed
product information
Product ID :
ALX-350-245
Catalog Number :
ALX-350-245-MC01
Product Name :
Lactacystin (native)
Product Type :
Biochemical
Size :
0.1 mg
list of Pubmed id :
15992382, 11399945, 11082705, 9662024, 9569046, 9562973, 9535824, 8885994, 8878553, 8810339
Product Description :
Cell permeable and irreversible proteasome inhibitor. Specifically inhibits 26S proteasome (MCP; multicatalytic proteinase complex). Blocks proteasome activity by targeting the catalytic β-subunit. Has no effect on serine or cysteine proteases. Induces apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation by inhibiting IκB degradation. Inhibits the ubiquitin proteasome pathway in cell culture (IC50=10µM). Inhibits cathepsin A. Upregulates HSP70 and HSP22, suggesting an initial neuroprotective pathway.
Purity :
≥97% (HPLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.