This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Deguelin
catalog :
ALX-350-118-M005
quantity :
5 mg
citations: 7
Reference
Lee H. Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells. Biochem Pharmacol. 2004;68:1119-24 pubmed
Hail N, Lotan R. Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics. Apoptosis. 2004;9:437-47 pubmed
Lee H, Suh Y, Kosmeder J, Pezzuto J, Hong W, Kurie J. Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. Clin Cancer Res. 2004;10:1074-9 pubmed
Ito C, Itoigawa M, Kojima N, Tan H, Takayasu J, Tokuda H, et al. Cancer chemopreventive activity of rotenoids from Derris trifoliata. Planta Med. 2004;70:8-11 pubmed
Chun K, Kosmeder J, Sun S, Pezzuto J, Lotan R, Hong W, et al. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst. 2003;95:291-302 pubmed
Murillo G, Salti G, Kosmeder J, Pezzuto J, Mehta R. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer. 2002;38:2446-54 pubmed
Udeani G, Gerhauser C, Thomas C, Moon R, Kosmeder J, Kinghorn A, et al. Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res. 1997;57:3424-8 pubmed
product information
Product ID :
ALX-350-118
Catalog Number :
ALX-350-118-M005
Product Name :
Deguelin
Product Type :
Biochemical
Size :
5 mg
list of Pubmed id :
15313408, 15192326, 14871987, 14765285, 12591985, 12460790, 9270008
Product Description :
Inhibitor of Akt (protein kinase B; PKB) in an in vitro lung carcinogenesis progression model. Inhibits cell proliferation - cells accumulate in the G2-M phase of the cell cycle. Premalignant and malignant human brochial epithelial cells are highly sensitive to deguelin compared to normal cells. Induces apoptosis. Exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Inhibits cyclooxygenase-2 (COX-2) expression.
ALTnames :
[-]-Deguelin
Purity :
≥95% (HPLC)
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.