Rottlerin | Enzo Life Sciences ALX-350-075-M025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Rottlerin

catalog :

ALX-350-075-M025

quantity :

25 mg

citations: 7

Reference
Balgi A, Fonseca B, Donohue E, Tsang T, Lajoie P, Proud C, et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS ONE. 2009;4:e7124 pubmed publisher
Song K, Kim J, Yun E, Kim Y, Seo K, Park J, et al. Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis. Autophagy. 2008;4:650-8 pubmed
Soltoff S. Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta. Trends Pharmacol Sci. 2007;28:453-8 pubmed
Ryan A, Gray N, Lowe P, Chung C. Effect of detergent on "promiscuous" inhibitors. J Med Chem. 2003;46:3448-51 pubmed
Gschwendt M, Kittstein W, Marks F. Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994;338:85-8 pubmed
Gschwendt M, Muller H, Kielbassa K, Zang R, Kittstein W, Rincke G, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994;199:93-8 pubmed
Gschwendt M, Kittstein W, Furstenberger G, Marks F. The mouse ear edema: a quantitatively evaluable assay for tumor promoting compounds and for inhibitors of tumor promotion. Cancer Lett. 1984;25:177-85 pubmed

product information

Product ID :

ALX-350-075

Catalog Number :

ALX-350-075-M025

Product Name :

Rottlerin

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

19771169, 18424913, 17692392, 12877581, 8307162, 8123051, 6509437

Product Description :

Mitochondrial uncoupler that depolarizes the mitochondrial membrane potential, reduces cellular ATP levels, activates 5‘-AMP-activated protein kinase (AMPK) and affects mitochondrial production of reactive oxygen species (ROS). Potent activator of multiple Ca2+-sensitive K+ channels. Blocks several kinases and non-kinase proteins in vitro. Has been widely-used as a selective inhibitor of protein kinase Cδ (PKCδ) (IC50=3-6µM). Although there is extensive published documentation to support the use of rottlerin as a selective PKCδ inhibitor, there has been some controversy in the literature over this claim. Some of this controversy may arise from the fact that rottlerin is a promiscuous inhibitor and therefore may not always display the same properties as would be expected from a classical 1:1 inhibitor. However, there are studies indicate that rottlerin has no direct effect on PKCδ and that it should not be used to determine the involvement of PKCδ in biological processes. Induces autophagy by inhibition of mTORC1 signaling.

ALTnames :

Mallotoxin

Purity :

≥98% (TLC)

Storage :

Ambient