Hypericin (native) | Enzo Life Sciences ALX-350-030-M001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Hypericin (native)

catalog :

ALX-350-030-M001

quantity :

1 mg

citations: 10

Reference
Kiesslich T, Krammer B, Plaetzer K. Cellular mechanisms and prospective applications of hypericin in photodynamic therapy. Curr Med Chem. 2006;13:2189-204 pubmed
Kubin A, Wierrani F, Burner U, Alth G, Grünberger W. Hypericin--the facts about a controversial agent. Curr Pharm Des. 2005;11:233-53 pubmed
Agostinis P, Assefa Z, Vantieghem A, Vandenheede J, Merlevede W, De Witte P. Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin. Adv Enzyme Regul. 2000;40:157-82 pubmed
Lee K, Kim J, Rho Y, Chang S, Jung J, Park J, et al. Hypericin induces both differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull. 1999;22:1271-4 pubmed
Chaloupka R, Petit P, Israel N, Sureau F. Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway. FEBS Lett. 1999;462:295-301 pubmed
Assefa Z, Vantieghem A, Declercq W, Vandenabeele P, Vandenheede J, Merlevede W, et al. The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin. J Biol Chem. 1999;274:8788-96 pubmed
Vantieghem A, Assefa Z, Vandenabeele P, Declercq W, Courtois S, Vandenheede J, et al. Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis. FEBS Lett. 1998;440:19-24 pubmed
Agostinis P, Vandenbogaerde A, Donella Deana A, Pinna L, Lee K, Goris J, et al. Photosensitized inhibition of growth factor-regulated protein kinases by hypericin. Biochem Pharmacol. 1995;49:1615-22 pubmed
Lavie G, Mazur Y, Lavie D, Meruelo D. The chemical and biological properties of hypericin--a compound with a broad spectrum of biological activities. Med Res Rev. 1995;15:111-9 pubmed
Diwu Z. Novel therapeutic and diagnostic applications of hypocrellins and hypericins. Photochem Photobiol. 1995;61:529-39 pubmed

product information

Product ID :

ALX-350-030

Catalog Number :

ALX-350-030-M001

Product Name :

Hypericin (native)

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

16918348, 15638760, 10828351, 10746153, 10622714, 10085120, 9862416, 7786302, 7739292, 7568399

Product Description :

A potent and selective inhibitor of protein kinase C (IC50=3.4µM). Anti-viral and anti-retroviral actitity. Displays antineoplastic and antitumor actitities. Most activities require light activation. Induces apoptosis in neuroblastoma cells at 1µM or above (IC50=0.1µM at 29 mW/cm2 (tungsten light)). Inhibitition of other kinases (e.g. EGFR-PTK, CKII and MAP kinase). Bright red fluorescence emissino and photostability. Antidepressant.

Purity :

≥98% (HPLC)

Storage :

+4°C