Genistein (synthetic) | Enzo Life Sciences ALX-350-006-M050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Genistein (synthetic)

catalog :

ALX-350-006-M050

quantity :

50 mg

citations: 10

Reference
Breit A, Besik V, Solinski H, Muehlich S, Glas E, Yarwood S, et al. Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation. Mol Endocrinol. 2015;29:445-59 pubmed publisher
Sarkar F, Adsule S, Padhye S, Kulkarni S, Li Y. The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy. Mini Rev Med Chem. 2006;6:401-7 pubmed
Bairey Merz C, Johnson B, Braunstein G, Pepine C, Reis S, Paul Labrador M, et al. Phytoestrogens and lipoproteins in women. J Clin Endocrinol Metab. 2006;91:2209-13 pubmed
Dewell A, Hollenbeck P, Hollenbeck C. Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations. J Clin Endocrinol Metab. 2006;91:772-80 pubmed
Huang Y, Cao S, Nagamani M, Anderson K, Grady J, Lu L. Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones. J Clin Endocrinol Metab. 2005;90:3956-62 pubmed
Bazuine M, van den Broek P, Maassen J. Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2005;326:511-4 pubmed
Dijsselbloem N, Vanden Berghe W, De Naeyer A, Haegeman G. Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy. Biochem Pharmacol. 2004;68:1171-85 pubmed
Opałka M, Kaminska B, Ciereszko R, Dusza L. Genistein affects testosterone secretion by Leydig cells in roosters (Gallus gallus domesticus). Reprod Biol. 2004;4:185-93 pubmed
Sarkar F, Li Y. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev. 2002;21:265-80 pubmed
Lee D, Lee S. Genistein, a soy isoflavone, is a potent alpha-glucosidase inhibitor. FEBS Lett. 2001;501:84-6 pubmed

product information

Product ID :

ALX-350-006

Catalog Number :

ALX-350-006-M050

Product Name :

Genistein (synthetic)

Product Type :

Biochemical

Size :

50 mg

list of Pubmed id :

25584415, 16613577, 16595605, 16384855, 15840745, 15582607, 15313415, 15297892, 12549765, 11457461

Product Description :

Tyrosine protein kinase inhibitor. Inhibits phosphorylation of EGFR kinase. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits topoisomerase II activity in vivo. Produces cell cycle arrest and apoptosis. Potent inhibitor of α-glucosidase, IC50 = 50nM.Direct inhibitor of insulin-induced glucose uptake in adipocytes (IC50=20µM).

ALTnames :

4',5,7-Trihydroxyisoflavone

Purity :

≥98% (HPLC)

Storage :

-20°C