Okadaic acid (high purity) | Enzo Life Sciences ALX-350-003-C025 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Okadaic acid (high purity)

catalog :

ALX-350-003-C025

quantity :

25 µg

citations: 10

Reference
Wong P, Feng Y, Wang J, Shi R, Jiang X. Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A. Nat Commun. 2015;6:8048 pubmed publisher
Iacobazzi D, Garaeva I, Albertario A, Cherif M, Angelini G, Caputo M, et al. Protein Phosphatase 1 Beta is Modulated by Chronic Hypoxia and Involved in the Angiogenic Endothelial Cell Migration. Cell Physiol Biochem. 2015;36:384-94 pubmed publisher
Chang H, Hou W. Retinoic acid modulates interferon-Î³ production by hepatic natural killer T cells via phosphatase 2A and the extracellular signal-regulated kinase pathway. J Interferon Cytokine Res. 2015;35:200-12 pubmed publisher
Park M, Choi Y, Lee H, Kim K, Lim J, Lee M, et al. Dephosphorylation of CCAAT/enhancer-binding protein ? by protein phosphatase 2A containing B56? is required at the early time of adipogenesis. Biochim Biophys Acta. 2014;1841:1608-18 pubmed publisher
Tomasella A, Blangy A, Brancolini C. A receptor-interacting protein 1 (RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1. J Biol Chem. 2014;289:25699-710 pubmed publisher
Wu M, Xie X, Xu Z, Xie L, Chen Z, Shou L, et al. PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/?-catenin pathway by phosphorylation and degradation of ?-catenin. Oncol Rep. 2014;32:513-22 pubmed publisher
Tang F, Zhang L, Xue G, Hynx D, Wang Y, Cron P, et al. hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme. Cancer Res. 2014;74:3779-89 pubmed publisher
Hanana H, Talarmin H, Pennec J, Droguet M, Morel J, Dorange G. Effect of okadaic acid on cultured clam heart cells: involvement of MAPkinase pathways. Biol Open. 2012;1:1192-9 pubmed publisher
Hanana H, Talarmin H, Pennec J, Droguet M, Gobin E, Marcorelle P, et al. Establishment of functional primary cultures of heart cells from the clam Ruditapes decussatus. Cytotechnology. 2011;63:295-305 pubmed publisher
Dick O, Bading H. Synaptic activity and nuclear calcium signaling protect hippocampal neurons from death signal-associated nuclear translocation of FoxO3a induced by extrasynaptic N-methyl-D-aspartate receptors. J Biol Chem. 2010;285:19354-61 pubmed publisher

product information

Product ID :

ALX-350-003

Catalog Number :

ALX-350-003-C025

Product Name :

Okadaic acid (high purity)

Product Type :

Biochemical

Size :

25 µg

list of Pubmed id :

26310906, 25967976, 25343668, 25152162, 25096578, 24926961, 24872389, 23259053, 21424582, 20404335

Product Description :

Okadaic acid is a naturally occuring polyether toxin produced by marine dinoflagellates. It is a potent and selective inhibitor of protein phosphatases, inhibiting PP2A completely at 1nM and PP1 at higher concentrations (IC50=10-15nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is not inhibited. This selectivity is the basis for an improved identification and quantification procedure for these enzymes. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyorsine phosphatase. Non-phorbol type tumor promoter. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells, but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Is a tumor promoter. Has shown contractile effects on smooth muscle and heart muscle. Significantly increases cyclin B1 expression in adult neurons.

ALTnames :

Halochondrine A, 9,10-Deepithio-9,10-didehydroacanthifolicin

Purity :

≥98% (TLC)

Storage :

-20°C