This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Dynasore
catalog :
ALX-270-502-M025
quantity :
25 mg
citations: 9
Reference
Choi H, Dikalova A, Stark R, Lamb F. c-Jun N-terminal kinase attenuates TNFα signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells. Free Radic Biol Med. 2015;86:219-27 pubmed publisher
Hu C, Cheng C, Wu J, Pan S, Wu W. PKCε-mediated c-Met endosomal processing directs fluctuant c-Met-JNK-paxillin signaling for tumor progression of HepG2. Cell Signal. 2015;27:1544-55 pubmed publisher
Barrias E, Reignault L, de Souza W, Carvalho T. Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages. PLoS ONE. 2010;5:e7764 pubmed publisher
Husmann M, Beckmann E, Boller K, Kloft N, Tenzer S, Bobkiewicz W, et al. Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis. FEBS Lett. 2009;583:337-44 pubmed publisher
Kirchhausen T, Macia E, Pelish H. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol. 2008;438:77-93 pubmed publisher
Nankoe S, Sever S. Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation. Trends Cell Biol. 2006;16:607-9 pubmed
Massol R, Boll W, Griffin A, Kirchhausen T. A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc Natl Acad Sci U S A. 2006;103:10265-10270 pubmed publisher
Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006;10:839-50 pubmed
Ling A, Hong Y, Gonzalez J, Gregor V, Polinsky A, Kuki A, et al. Identification of alkylidene hydrazides as glucagon receptor antagonists. J Med Chem. 2001;44:3141-9 pubmed
product information
Product ID :
ALX-270-502
Catalog Number :
ALX-270-502-M025
Product Name :
Dynasore
Product Type :
Biochemical
Size :
25 mg
list of Pubmed id :
26001727, 25778903, 20098746, 19101547, 18413242, 17064900, 16798879, 16740485, 11543683
Product Description :
Small molecule GTPase inhibitor targeting Dynamin-1, Dynamin-2 and Drp1 (mitochondrial Dynamin). Noncompetitive inhibitor of Dynamin GTPase activity. Blocks Dynamin-dependent endocytosis in cells (including neurons). Fast acting (seconds). Strong, dose dependent block of the traffic and accumulation of transferrin with 80µM dynasore (IC50 = 15µM). Has also been shown to block human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Purity :
≥98% (HPLC, TLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.