This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
SB 225002
catalog :
ALX-270-478-M005
quantity :
5 mg
citations: 4
Reference
Braber S, Overbeek S, Koelink P, Henricks P, Zaman G, Garssen J, et al. CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1. Eur J Pharmacol. 2011;668:443-9 pubmed publisher
Wang B, Hendricks D, Wamunyokoli F, Parker M. A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer. Cancer Res. 2006;66:3071-7 pubmed
Catusse J, Liotard A, Loillier B, Pruneau D, Paquet J. Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2. Biochem Pharmacol. 2003;65:813-21 pubmed
White J, Lee J, Young P, Hertzberg R, Jurewicz A, Chaikin M, et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem. 1998;273:10095-8 pubmed
product information
Product ID :
ALX-270-478
Catalog Number :
ALX-270-478-M005
Product Name :
SB 225002
Product Type :
Biochemical
Size :
5 mg
list of Pubmed id :
21458445, 16540656, 12628493, 9553055
Product Description :
Potent and selective antagonist of CXCR2 chemokine receptor (IC50=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC50=8nM) and GROα-mediated (IC50=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.
ALTnames :
N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
Purity :
≥98% (HPLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.